ncFO:与Ferroptosis相关的已治愈和预测的ncRNA的综合资源。

IF 11.5 2区 生物学 Q1 GENETICS & HEREDITY
Shunheng Zhou , Yu’e Huang , Jiani Xing , Xu Zhou , Sina Chen , Jiahao Chen , Lihong Wang , Wei Jiang
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引用次数: 1

摘要

脱铁症是一种由脂质氢过氧化物积累驱动的调节性细胞死亡。调节脱铁症可能有利于癌症的治疗。非编码RNA(ncRNA)是一类通常不能编码蛋白质的RNA转录物,已被证明在调节脱铁性贫血中发挥关键作用。在此,我们开发了ncFO,即ncRNA脱铁症关联数据库,以记录与脱铁症相关的手动策划和预测的ncRNA。ncFO总共包含90个实验验证的条目,包括46个微小RNA(miRNA)、21个长非编码RNA(lncRNA)和17个环状RNA(circRNA)。此外,ncFO还结合了两种基于ncRNA和脱铁性贫血基因调控和共表达的在线预测工具。使用默认参数,我们通过调节获得了3260个预测条目,包括598个miRNA和178个lncRNA,以及通过20种癌症类型的8000多个样本中的ncRNA-凋亡基因共表达获得的2592661个预测条目(包括967个miRNAs和9632个lncRNAs)。每个条目的详细信息包括ncRNA名称、疾病、物种、组织、靶点、调控、发表时间和PubMed标识符。ncFO还提供ncRNA的存活分析和差异表达分析。总之,ncFO提供了一个用户友好的平台来搜索和预测脱铁相关的ncRNA,这可能有助于研究脱铁症并发现癌症治疗的潜在靶点。ncFO可访问http://www.jianglab.cn/ncFO/.
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ncFO: A Comprehensive Resource of Curated and Predicted ncRNAs Associated with Ferroptosis

Ferroptosis is a form of regulated cell death driven by the accumulation of lipid hydroperoxides. Regulation of ferroptosis might be beneficial to cancer treatment. Non-coding RNAs (ncRNAs) are a class of RNA transcripts that generally cannot encode proteins and have been demonstrated to play critical roles in regulating ferroptosis. Herein, we developed ncFO, the ncRNA–ferroptosis association database, to document the manually curated and predicted ncRNAs that are associated with ferroptosis. Collectively, ncFO contains 90 experimentally verified entries, including 46 microRNAs (miRNAs), 21 long non-coding RNAs (lncRNAs), and 17 circular RNAs (circRNAs). In addition, ncFO also incorporates two online prediction tools based on the regulation and co-expression of ncRNA and ferroptosis genes. Using default parameters, we obtained 3260 predicted entries, including 598 miRNAs and 178 lncRNAs, by regulation, as well as 2,592,661 predicted entries, including 967 miRNAs and 9632 lncRNAs, by ncRNA–ferroptosis gene co-expression in more than 8000 samples across 20 cancer types. The detailed information of each entry includes ncRNA name, disease, species, tissue, target, regulation, publication time, and PubMed identifier. ncFO also provides survival analysis and differential expression analysis for ncRNAs. In summary, ncFO offers a user-friendly platform to search and predict ferroptosis-associated ncRNAs, which might facilitate research on ferroptosis and discover potential targets for cancer treatment. ncFO can be accessed at http://www.jianglab.cn/ncFO/.

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来源期刊
Genomics, Proteomics & Bioinformatics
Genomics, Proteomics & Bioinformatics Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
14.30
自引率
4.20%
发文量
844
审稿时长
61 days
期刊介绍: Genomics, Proteomics and Bioinformatics (GPB) is the official journal of the Beijing Institute of Genomics, Chinese Academy of Sciences / China National Center for Bioinformation and Genetics Society of China. It aims to disseminate new developments in the field of omics and bioinformatics, publish high-quality discoveries quickly, and promote open access and online publication. GPB welcomes submissions in all areas of life science, biology, and biomedicine, with a focus on large data acquisition, analysis, and curation. Manuscripts covering omics and related bioinformatics topics are particularly encouraged. GPB is indexed/abstracted by PubMed/MEDLINE, PubMed Central, Scopus, BIOSIS Previews, Chemical Abstracts, CSCD, among others.
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