无多胞症的肠病毒性脑膜炎:一项成人回顾性观察研究。

IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES
Japanese journal of infectious diseases Pub Date : 2023-11-22 Epub Date: 2023-06-30 DOI:10.7883/yoken.JJID.2023.123
Dongkeun Roh, Woochan Jeon, Jisook Lee
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引用次数: 0

摘要

反转录聚合酶链反应(RT-PCR)证实的肠病毒(EV)脑膜炎无多细胞增多症以前仅在儿童中报道过。在这项研究中,我们检查了成人无多细胞增多的EV脑膜炎的频率,并比较了其临床特征。我们回顾性分析了脑脊液(CSF) RT-PCR确诊的成年EV脑膜炎患者的资料。在本研究纳入的17例患者中,58.8%的患者未出现多细胞增多症。多细胞增多症组和非多细胞增多症组的中位年龄和临床症状无差异。从出现脑膜炎症状到腰椎穿刺在季节变化或时间上没有统计学上的显著差异。细胞增多症患者外周血白细胞计数明显高于无细胞增多症患者。非细胞增多症组脑脊液中位压呈升高趋势。脑脊液压力高于正常值的患者多见于非多细胞增多症组。两组脑脊液蛋白中位数均高于正常值。我们证实了成人无多胞症的EV脑膜炎的高频率。在EV流行期间,当脑膜炎症状突出,脑脊液蛋白水平和压力高时,即使脑脊液白细胞计数正常,也需要使用RT-PCR进行准确诊断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Enterovirus Meningitis without Pleocytosis: a Retrospective Observational Study in Adults.

Reverse-transcription polymerase chain reaction (RT-PCR)-confirmed enterovirus (EV) meningitis without pleocytosis has only been previously reported in children. In this study, we examined the frequency of EV meningitis without pleocytosis in adults and compared its clinical features. We retrospectively analyzed the data of adult patients with EV meningitis confirmed using cerebrospinal fluid (CSF) RT-PCR. Among the 17 patients included in this study, 58.8% showed no pleocytosis. The median age and clinical symptoms did not differ between the pleocytosis and non-pleocytosis groups. There were no statistically significant differences in seasonal variation or time from the onset of meningitis symptoms to lumbar puncture. The peripheral white blood cell (WBC) count in patients with pleocytosis was significantly higher than that in patients without pleocytosis. The median CSF pressure showed a higher trend in the non-pleocytosis group. Patients with CSF pressures higher than normal were more common in the non-pleocytosis group. The median CSF protein values were higher than the normal values in both groups. We confirmed the high frequency of EV meningitis without pleocytosis in adults. Accurate diagnosis using RT-PCR is necessary when meningitis symptoms are prominent during an EV epidemic, and CSF protein levels and pressure are high, even if the CSF WBC count is normal.

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来源期刊
CiteScore
4.50
自引率
4.50%
发文量
172
审稿时长
2 months
期刊介绍: Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.
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