皮肌炎患者与COVID-19感染具有部分相似的转录组特征。

IF 3.3 4区医学 Q3 IMMUNOLOGY

Autoimmunity Pub Date : 2023-12-01 DOI:10.1080/08916934.2023.2220984

Yiying Yang, Jie Song, Hongjun Zhao, Huali Zhang, Muyao Guo

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引用次数: 0

摘要

皮肌炎（DM）是一种自身免疫性疾病，主要影响皮肤和骨骼肌。病毒感染和I型干扰素相关信号通路在皮肌炎的发病机制中起着重要作用。在这项研究中，我们发现DM患者的皮肤和新冠肺炎患者的皮肤具有相似的转录谱，并基于生物信息学分析确定了参与皮肌炎的关键基因。这些枢纽基因可能作为糖尿病早期诊断和治疗的潜在生物标志物，包括MX1、ISG15、IFIT3、IFIT1、RSAD2、IFIT2、IFI6、XAF1、IRF9、MX2。

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Patients with dermatomyositis shared partially similar transcriptome signature with COVID-19 infection.

Dermatomyositis (DM) is an autoimmune disease that primarily affects the skin and skeletal muscle. Virus infection and type I interferon-related signaling pathways play an important role in the pathogenesis of dermatomyositis. In this study, we found that the skin of patients with DM and the skin of patients with COVID-19 have similar transcriptional profiles, and identified key genes involved in dermatomyositis based on bioinformatics analysis. These hub-genes might be served as potential biomarkers for the early diagnosis and therapy of DM, including MX1, ISG15, IFIT3, IFIT1, RSAD2, IFIT2, IFI6, XAF1, IRF9, MX2.

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来源期刊

Autoimmunity 医学-免疫学

CiteScore

5.70

自引率

8.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Autoimmunity is an international, peer reviewed journal that publishes articles on cell and molecular immunology, immunogenetics, molecular biology and autoimmunity. Current understanding of immunity and autoimmunity is being furthered by the progress in new molecular sciences that has recently been little short of spectacular. In addition to the basic elements and mechanisms of the immune system, Autoimmunity is interested in the cellular and molecular processes associated with systemic lupus erythematosus, rheumatoid arthritis, Sjogren syndrome, type I diabetes, multiple sclerosis and other systemic and organ-specific autoimmune disorders. The journal reflects the immunology areas where scientific progress is most rapid. It is a valuable tool to basic and translational researchers in cell biology, genetics and molecular biology of immunity and autoimmunity.