非垂体GH对组织微环境的调节。

IF 4.1 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Endocrine-related cancer Pub Date : 2023-07-01 DOI:10.1530/ERC-23-0028

Vera Chesnokova, Shlomo Melmed

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引用次数: 3

摘要

非垂体生长激素(npGH)的表达在垂体外组织中得到了很好的证实，但对npGH的生理作用的了解仍然相当有限。促瘤性npGH对肿瘤微环境的影响已作了综述。我们将重点研究npGH在非肿瘤组织中的自分泌/旁分泌作用，并讨论其在正常组织微环境中的作用机制。我们讨论了npGH在调节干细胞、内皮细胞、免疫细胞和上皮细胞中的组织特异性作用，并强调了npGH在组织衰老中的相关作用。

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Non-pituitary GH regulation of the tissue microenvironment.

Non-pituitary growth hormone (npGH) expression is well established in extrapituitary tissues, but an understanding of the physiological role of npGH remains rather limited. Pro-tumorigenic npGH impacting the tumor microenvironment has been reviewed. We focus here on autocrine/paracrine npGH effects in non-tumorous tissues and discuss its mechanisms of action in the normal tissue microenvironment. We address the tissue-specific effects of npGH in regulating stem, endothelial, immune, and epithelial cells and highlight the related role of npGH-associated changes in tissue aging.

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来源期刊

Endocrine-related cancer 医学-内分泌学与代谢

CiteScore

7.80

自引率

2.60%

发文量

138

审稿时长

6-12 weeks

期刊介绍： Endocrine-Related Cancer is an official flagship journal of the Society for Endocrinology and is endorsed by the European Society of Endocrinology, the United Kingdom and Ireland Neuroendocrine Society, and the Japanese Hormones and Cancer Society. Endocrine-Related Cancer provides a unique international forum for the publication of high quality original articles describing novel, cutting edge basic laboratory, translational and clinical investigations of human health and disease focusing on endocrine neoplasias and hormone-dependent cancers; and for the publication of authoritative review articles in these topics. Endocrine neoplasias include adrenal cortex, breast, multiple endocrine neoplasia, neuroendocrine tumours, ovary, prostate, paraganglioma, parathyroid, pheochromocytoma pituitary, testes, thyroid and hormone-dependent cancers. Neoplasias affecting metabolism and energy production such as bladder, bone, kidney, lung, and head and neck, are also considered.