牛初乳、乳和血清免疫球蛋白G中选定特异性抗体水平的比较。

IF 1.1 4区 农林科学 Q2 Veterinary
Stacey R Lacoste, John A Ellis, Manuel Campos, Dana E Ramsay, Deborah M Haines
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引用次数: 0

摘要

含有免疫球蛋白G (IgG)的商业产品来源于初乳、牛奶和/或血清,可用于补充或替代新生奶牛的母体初乳。为了确定牛奶和血清IgG的抗体特异性是否与初乳IgG不同,我们采集了24头奶牛的血清、初乳(产后1至2小时)和牛奶(产后5天)。采用酶联免疫吸附法(elisa)检测8种常见病原菌的特异性抗体[IgG类(H&L)]。对其中3种病原体进行免疫球蛋白G1和IgG2亚类特异性elisa检测。与牛奶IgG相比,初乳IgG对轮状病毒IgG (H&L)和IgG1以及牛呼吸道合胞病毒(BRSV)、牛副流感病毒(BPI3V)、金黄色葡萄球菌、大肠杆菌F5 (K99)和牛冠状病毒IgG (H&L)具有更高的特异性。与血清IgG相比,初乳IgG含有更多的BRSV (IgG1)、轮状病毒(IgG1)和BRSV、牛疱疹病毒-1 (BHV-1)、BPI3V、大肠杆菌F5 (K99)和ubercoccus uberis特异性IgG (H&L)抗体。与血清相比,牛奶中含有更多的BRSV、BHV-1和BPI3V、igg1特异性BRSV和轮状病毒IgG (H&L)抗体。这些数据表明,与来自牛奶或血清的IgG相比,来自初乳的IgG可提供更多针对这些小牛地方性病原体的特异性抗体。此外,IgG1亚类在牛奶和初乳中占主导地位,两者都提供相似的抗体谱。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of the levels of selected specific antibodies in the immunoglobulin G of colostrum versus milk and serum in dairy cows (Bos taurus).

Commercial products containing immunoglobulin G (IgG) sourced from colostrum, milk, and/or serum may be used to supplement or replace maternal colostrum in newborn dairy calves. To determine if antibody specificities in bovine milk and serum IgG differ from colostrum IgG, we sampled serum, colostrum (1 to 2 hours post-partum), and milk (day 5 post-partum) from 24 dairy heifers or cows. Specific antibodies [IgG class (H&L)] to 8 common pathogens were measured using enzyme-linked immunosorbent assays (ELISAs). Immunoglobin G1 and IgG2 subclass-specific ELISAs were performed for 3 of these pathogens. Colostrum-derived IgG contained more specific antibodies to rotavirus [IgG (H&L) and IgG1] and to IgG (H&L) of bovine respiratory syncytial virus (BRSV), bovine parainfluenza-3 virus (BPI3V), Staphylococcus aureus, Escherichia coli F5 (K99), and bovine coronavirus than milk IgG. Colostral IgG contained more antibodies to BRSV (IgG1), rotavirus (IgG1), and IgG (H&L) specific for BRSV, bovine herpesvirus-1 (BHV-1), BPI3V, E. coli F5 (K99), and Streptococcus uberis than serum IgG. Compared to serum, milk contained more IgG (H&L) antibody to BRSV, BHV-1, and BPI3V, IgG1-specific BRSV, and rotavirus. These data indicate that IgG derived from colostrum delivers more specific antibodies to these endemic pathogens of calves compared to IgG sourced from milk or serum. In addition, the IgG1 subclass predominates in milk and colostrum, and both deliver a similar spectrum of antibodies.

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来源期刊
CiteScore
1.80
自引率
0.00%
发文量
58
审稿时长
>24 weeks
期刊介绍: The Canadian Journal of Veterinary Research, published by the Canadian Veterinary Medical Association, is Canada''s only veterinary research publication. This quarterly peer-reviewed online-only journal has earned a wide international readership through the publishing of high quality scientific papers in the field of veterinary medicine. The Journal publishes the results of original research in veterinary and comparative medicine.
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