残余脂蛋白颗粒与心血管疾病风险

IF 6.1 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Ronald M. Krauss MD (Professor of Pediatrics and Medicine), Sarah M. King PhD
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引用次数: 3

摘要

乳糜微粒和极低密度脂蛋白(VLDL)的血管内分解代谢产生一系列部分脂解的残余颗粒。它们的血浆水平和性质受到脂肪酶、脂质转移蛋白和可交换脂蛋白含量的影响。后者中特别重要的是apoE,它介导肝脏结合和残余物的摄取,以及apoCIII,它可以延缓这一过程。在其血浆转运过程中,残余物可以获得促进动脉粥样硬化性心血管疾病(ASCVD)发展的病理特性,包括胆固醇含量增加以及血栓形成和炎症介质的转运。通过各种分析技术测定的富含胆固醇的残余颗粒水平与ASCVD的发生率显著相关,在apoE2基因亚型纯合的血脂异常患者中最为显著。有必要进行进一步的研究,以开发能够更好地捕捉残余脂蛋白亚群的病理影响的临床分析,并测试降低其水平的治疗对ASCVD的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Remnant lipoprotein particles and cardiovascular disease risk

Intravascular catabolism of chylomicrons and very low-density lipoproteins (VLDLs) gives rise to a spectrum of partially lipolyzed remnant particles. Their plasma levels and properties are influenced by lipases, lipid transfer proteins, and content of exchangeable lipoproteins. Particularly important among the latter are apoE, which mediates hepatic binding and uptake of remnants, and apoCIII, which can retard this process. In the course of their plasma transit, remnants can acquire pathologic properties that promote the development of atherosclerotic cardiovascular disease (ASCVD) including increased cholesterol content and transport of thrombogenic and inflammatory mediators. Levels of cholesterol-enriched remnant particles determined by various analytic techniques have been significantly linked to the incidence of ASCVD, most dramatically in dyslipidemic patients homozygous for the apoE2 genetic isoform. Further research is warranted for development of clinical assays that can better capture the pathologic impact of remnant lipoprotein subspecies, and for testing the impact on ASCVD of therapies that reduce their levels.

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来源期刊
CiteScore
11.90
自引率
0.00%
发文量
77
审稿时长
6-12 weeks
期刊介绍: Best Practice & Research Clinical Endocrinology & Metabolism is a serial publication that integrates the latest original research findings into evidence-based review articles. These articles aim to address key clinical issues related to diagnosis, treatment, and patient management. Each issue adopts a problem-oriented approach, focusing on key questions and clearly outlining what is known while identifying areas for future research. Practical management strategies are described to facilitate application to individual patients. The series targets physicians in practice or training.
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