Orly Leiva, Andrew Jenkins, Rachel P Rosovsky, Rebecca K Leaf, Katayoon Goodarzi, Gabriela Hobbs
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引用次数: 1
摘要
骨髓增生性肿瘤(mpn)患者发生心血管疾病(CVD)的风险增加，包括急性冠状动脉综合征(ACS)。然而，缺乏关于发生ACS的MPN患者的长期结局和ACS住院后全因死亡或CV事件的危险因素的数据。我们对41例MPN确诊后ACS住院的MPN患者进行了单中心研究。在ACS住院后中位随访80个月后，31例(76%)发生死亡或心血管事件(心肌梗死、缺血性卒中或心力衰竭住院)。在多变量Cox比例风险回归后，MPN诊断后12个月内的ACS指数(HR 3.84, 95% CI 1.44-10.19)、WBC≥20 K/µL (HR 9.10, 95% CI 2.71-30.52)、JAK2突变(HR 3.71, 95% CI 1.22-11.22)和既往CVD (HR 2.60, 95% CI 1.12-6.08)与死亡或CV事件增加相关。需要进一步的研究来改善这类患者的心血管预后。
Risk Factors for Death or Cardiovascular Events after Acute Coronary Syndrome in Patients with Myeloproliferative Neoplasms.
Patients with myeloproliferative neoplasms (MPNs) are at increased risk of cardiovascular disease (CVD), including acute coronary syndrome (ACS). However, data on long-term outcomes of patients with MPN who have had ACS and risk factors for all-cause death or CV events post-ACS hospitalization are lacking. We conducted a single-center study of 41 consecutive patients with MPN with ACS hospitalization after MPN diagnosis. After a median follow-up of 80 months after ACS hospitalization, 31 (76%) experienced death or a CV event (myocardial infarction, ischemic stroke, or heart failure hospitalization). After multivariable Cox proportional hazards regression, index ACS within 12 months of MPN diagnosis (HR 3.84, 95% CI 1.44-10.19), WBC ≥ 20 K/µL (HR 9.10, 95% CI 2.71-30.52), JAK2 mutation (HR 3.71, 95% CI 1.22-11.22), and prior CVD (HR 2.60, 95% CI 1.12-6.08) were associated with increased death or CV events. Further studies are warranted to improve cardiovascular outcomes in this patient population.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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