肺炎克雷伯菌疫苗在动物模型中的研究

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Parivash Ranjbarian , Zahra Sobhi Amjad , Roya Chegene Lorestani , Ali Shojaeian , Mosayeb Rostamian
{"title":"肺炎克雷伯菌疫苗在动物模型中的研究","authors":"Parivash Ranjbarian ,&nbsp;Zahra Sobhi Amjad ,&nbsp;Roya Chegene Lorestani ,&nbsp;Ali Shojaeian ,&nbsp;Mosayeb Rostamian","doi":"10.1016/j.biologicals.2023.101678","DOIUrl":null,"url":null,"abstract":"<div><p><span>The treatment of </span><span><em>Klebsiella pneumoniae</em></span> is faced with challenges demanding the development of a vaccination strategy. However, no approved and globally available vaccine exists yet. This study aimed to systematically review all published data on <em>K. pneumoniae</em><span><span> vaccines in animal models. Without time restrictions, electronic databases were searched using appropriate keywords. The retrieved studies were screened and the data of those that matched our inclusion criteria were collected and analyzed. In total, 2027 records were retrieved; of which 35 studies were included for </span>systematic review<span>. The most frequently used animal model was BALB/c mice. Proteins, polysaccharides<span><span>, and their combinations (conjugates) were the most common vaccine candidates used. The amount of antigen, the route used for immunization, and the challenge strategy was varying in the studies and were chosen based on several factors such as the animal model, the type of antigen, and the schedule of immunization. Almost all studies claimed that their vaccine was effective/protective, indicated by increasing survival rate, reducing organ bacterial load, and eliciting protective antibody and/or </span>cytokine responses. Altogether, the information presented here will assist researchers to have a better look at the </span></span></span><em>K. pneumoniae</em> vaccine candidates and to take more effective steps in the future.</p></div>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Klebsiella pneumoniae vaccine studies in animal models\",\"authors\":\"Parivash Ranjbarian ,&nbsp;Zahra Sobhi Amjad ,&nbsp;Roya Chegene Lorestani ,&nbsp;Ali Shojaeian ,&nbsp;Mosayeb Rostamian\",\"doi\":\"10.1016/j.biologicals.2023.101678\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>The treatment of </span><span><em>Klebsiella pneumoniae</em></span> is faced with challenges demanding the development of a vaccination strategy. However, no approved and globally available vaccine exists yet. This study aimed to systematically review all published data on <em>K. pneumoniae</em><span><span> vaccines in animal models. Without time restrictions, electronic databases were searched using appropriate keywords. The retrieved studies were screened and the data of those that matched our inclusion criteria were collected and analyzed. In total, 2027 records were retrieved; of which 35 studies were included for </span>systematic review<span>. The most frequently used animal model was BALB/c mice. Proteins, polysaccharides<span><span>, and their combinations (conjugates) were the most common vaccine candidates used. The amount of antigen, the route used for immunization, and the challenge strategy was varying in the studies and were chosen based on several factors such as the animal model, the type of antigen, and the schedule of immunization. Almost all studies claimed that their vaccine was effective/protective, indicated by increasing survival rate, reducing organ bacterial load, and eliciting protective antibody and/or </span>cytokine responses. Altogether, the information presented here will assist researchers to have a better look at the </span></span></span><em>K. pneumoniae</em> vaccine candidates and to take more effective steps in the future.</p></div>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2023-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1045105623000167\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1045105623000167","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 1

摘要

肺炎克雷伯菌的治疗面临挑战,需要制定疫苗接种策略。然而,目前还没有批准的全球可用的疫苗。本研究旨在系统地回顾所有已发表的肺炎克雷伯菌疫苗动物模型数据。在没有时间限制的情况下,使用适当的关键字搜索电子数据库。对检索到的研究进行筛选,并收集和分析符合我们纳入标准的研究的数据。总共检索到2027条记录;其中35项研究被纳入系统综述。最常用的动物模型是BALB/c小鼠。蛋白质、多糖及其组合(偶联物)是最常用的候选疫苗。抗原的量、用于免疫的途径和攻击策略在研究中各不相同,并根据动物模型、抗原类型和免疫计划等几个因素进行选择。几乎所有的研究都声称他们的疫苗是有效的/具有保护性的,这表明他们的疫苗提高了存活率,减少了器官细菌负荷,并引发了保护性抗体和/或细胞因子反应。总之,这里提供的信息将有助于研究人员更好地了解肺炎克雷伯菌候选疫苗,并在未来采取更有效的措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Klebsiella pneumoniae vaccine studies in animal models

The treatment of Klebsiella pneumoniae is faced with challenges demanding the development of a vaccination strategy. However, no approved and globally available vaccine exists yet. This study aimed to systematically review all published data on K. pneumoniae vaccines in animal models. Without time restrictions, electronic databases were searched using appropriate keywords. The retrieved studies were screened and the data of those that matched our inclusion criteria were collected and analyzed. In total, 2027 records were retrieved; of which 35 studies were included for systematic review. The most frequently used animal model was BALB/c mice. Proteins, polysaccharides, and their combinations (conjugates) were the most common vaccine candidates used. The amount of antigen, the route used for immunization, and the challenge strategy was varying in the studies and were chosen based on several factors such as the animal model, the type of antigen, and the schedule of immunization. Almost all studies claimed that their vaccine was effective/protective, indicated by increasing survival rate, reducing organ bacterial load, and eliciting protective antibody and/or cytokine responses. Altogether, the information presented here will assist researchers to have a better look at the K. pneumoniae vaccine candidates and to take more effective steps in the future.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信