重新规划细胞新陈代谢,提高微生物细胞工厂的效率。

IF 8.1 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Critical Reviews in Biotechnology Pub Date : 2024-08-01 Epub Date: 2023-06-28 DOI:10.1080/07388551.2023.2208286
Qiang Ding, Liming Liu
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引用次数: 0

摘要

最近的研究越来越关注先进的生物技术工具、自我调节智能微生物和人工智能网络,以设计具有各种功能的微生物。微生物细胞工厂是利用可再生碳源改进药物、生物燃料和生物材料的生物生产的重要平台。然而,这些过程受细胞新陈代谢的影响很大,提高微生物细胞工厂的效率仍然是一个挑战。在这篇综述中,我们介绍了一种重编程细胞代谢的策略,以提高微生物细胞工厂进行化学生物合成的效率,从而增进我们对微生物生理学和代谢控制的了解。目前的方法主要集中在合成途径、代谢资源和细胞性能方面。这篇综述强调了重新编程细胞代谢的潜在生物技术策略,并为设计更智能的工业微生物提供了新的指导,使其在这一不断发展的领域有更广泛的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Reprogramming cellular metabolism to increase the efficiency of microbial cell factories.

Recent studies are increasingly focusing on advanced biotechnological tools, self-adjusting smart microorganisms, and artificial intelligent networks, to engineer microorganisms with various functions. Microbial cell factories are a vital platform for improving the bioproduction of medicines, biofuels, and biomaterials from renewable carbon sources. However, these processes are significantly affected by cellular metabolism, and boosting the efficiency of microbial cell factories remains a challenge. In this review, we present a strategy for reprogramming cellular metabolism to enhance the efficiency of microbial cell factories for chemical biosynthesis, which improves our understanding of microbial physiology and metabolic control. Current methods are mainly focused on synthetic pathways, metabolic resources, and cell performance. This review highlights the potential biotechnological strategy to reprogram cellular metabolism and provide novel guidance for designing more intelligent industrial microbes with broader applications in this growing field.

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来源期刊
Critical Reviews in Biotechnology
Critical Reviews in Biotechnology 工程技术-生物工程与应用微生物
CiteScore
20.80
自引率
1.10%
发文量
71
审稿时长
4.8 months
期刊介绍: Biotechnological techniques, from fermentation to genetic manipulation, have become increasingly relevant to the food and beverage, fuel production, chemical and pharmaceutical, and waste management industries. Consequently, academic as well as industrial institutions need to keep abreast of the concepts, data, and methodologies evolved by continuing research. This journal provides a forum of critical evaluation of recent and current publications and, periodically, for state-of-the-art reports from various geographic areas around the world. Contributing authors are recognized experts in their fields, and each article is reviewed by an objective expert to ensure accuracy and objectivity of the presentation.
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