David Pezoa, Carlos J Blondel, Fernando A Amaya, Carlos A Santiviago
{"title":"鸡沙门氏菌将T6SSSPI-19转移到缺乏T6SSSPI-6的鼠伤寒沙门氏菌，弥补了其在小鼠中的定植缺陷。","authors":"David Pezoa, Carlos J Blondel, Fernando A Amaya, Carlos A Santiviago","doi":"10.33073/pjm-2023-017","DOIUrl":null,"url":null,"abstract":"<p><p><i>Salmonella</i> genus harbors five Type VI Secretion System (T6SS) gene clusters. The T6SS encoded in SPI-6 (T6SS<sub>SPI-6</sub>) contributes to <i>Salmonella</i> Typhimurium colonization of chickens and mice, while the T6SS encoded in SPI-19 (T6SS<sub>SPI-19</sub>) of <i>Salmonella</i> Gallinarum contributes to chicken colonization. Interestingly, the T6SS<sub>SPI-19</sub> of <i>Salmonella</i> Gallinarum complemented the defect in chicken colonization of a <i>Salmonella</i> Typhimurium strain that lacks the T6SS<sub>SPI-6</sub>, suggesting that both T6SSs are interchangeable. Here we show that the transfer of <i>Salmonella</i> Gallinarum T6SS<sub>SPI-19</sub> complemented the defect in mice colonization of a <i>Salmonella</i> Typhimurium ΔT6SS<sub>SPI-6</sub> strain, indicating that both T6SSs are functionally redundant during host colonization.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1c/e1/pjm-72-2-pjm-2023-017.PMC10266286.pdf","citationCount":"0","resultStr":"{\"title\":\"Transfer of T6SS<sub>SPI-19</sub> from <i>Salmonella</i> Gallinarum to <i>Salmonella</i> Typhimurium Lacking T6SS<sub>SPI-6</sub> Complements its Colonization Defect in Mice.\",\"authors\":\"David Pezoa, Carlos J Blondel, Fernando A Amaya, Carlos A Santiviago\",\"doi\":\"10.33073/pjm-2023-017\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Salmonella</i> genus harbors five Type VI Secretion System (T6SS) gene clusters. The T6SS encoded in SPI-6 (T6SS<sub>SPI-6</sub>) contributes to <i>Salmonella</i> Typhimurium colonization of chickens and mice, while the T6SS encoded in SPI-19 (T6SS<sub>SPI-19</sub>) of <i>Salmonella</i> Gallinarum contributes to chicken colonization. Interestingly, the T6SS<sub>SPI-19</sub> of <i>Salmonella</i> Gallinarum complemented the defect in chicken colonization of a <i>Salmonella</i> Typhimurium strain that lacks the T6SS<sub>SPI-6</sub>, suggesting that both T6SSs are interchangeable. Here we show that the transfer of <i>Salmonella</i> Gallinarum T6SS<sub>SPI-19</sub> complemented the defect in mice colonization of a <i>Salmonella</i> Typhimurium ΔT6SS<sub>SPI-6</sub> strain, indicating that both T6SSs are functionally redundant during host colonization.</p>\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2023-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1c/e1/pjm-72-2-pjm-2023-017.PMC10266286.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.33073/pjm-2023-017\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.33073/pjm-2023-017","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Transfer of T6SSSPI-19 from Salmonella Gallinarum to Salmonella Typhimurium Lacking T6SSSPI-6 Complements its Colonization Defect in Mice.
Salmonella genus harbors five Type VI Secretion System (T6SS) gene clusters. The T6SS encoded in SPI-6 (T6SSSPI-6) contributes to Salmonella Typhimurium colonization of chickens and mice, while the T6SS encoded in SPI-19 (T6SSSPI-19) of Salmonella Gallinarum contributes to chicken colonization. Interestingly, the T6SSSPI-19 of Salmonella Gallinarum complemented the defect in chicken colonization of a Salmonella Typhimurium strain that lacks the T6SSSPI-6, suggesting that both T6SSs are interchangeable. Here we show that the transfer of Salmonella Gallinarum T6SSSPI-19 complemented the defect in mice colonization of a Salmonella Typhimurium ΔT6SSSPI-6 strain, indicating that both T6SSs are functionally redundant during host colonization.
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