肾肾损伤的抢救治疗:Rasburicase和Glucarpidase

IF 2.8 3区医学 Q2 UROLOGY & NEPHROLOGY

Seminars in nephrology Pub Date : 2022-11-01 DOI:10.1016/j.semnephrol.2023.151342

Sheron Latcha MD , Chintan V. Shah MD

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引用次数: 0

摘要

肿瘤溶解综合征(TLS)和高剂量甲氨蝶呤(HD MTX)毒性可在恶性肿瘤患者中出现潜在的严重并发症，包括急性肾损伤。使用毛囊酶和葡萄糖苷酶分别作为TLS和HD MTX毒性的挽救疗法的指南被临床医生广泛使用，旨在减轻器官毒性并降低癌症治疗的发病率和死亡率。本文讨论了TLS和HD mtx相关毒性的发病机制，了解这些治疗药物的作用机制，并对目前支持其使用的证据进行了综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Rescue Therapies for AKI in Onconephrology: Rasburicase and Glucarpidase

Tumor lysis syndrome (TLS) and high-dose methotrexate (HD MTX) toxicity can present with potentially severe complications, including acute kidney injury, in patients with malignancy. Guidelines for using rasburicase and glucarpidase as rescue therapies for TLS and HD MTX toxicity, respectively, are widely used by clinicians intending to mitigate organ toxicity and decrease morbidity and mortality as a consequence of cancer therapy. This review discusses the pathogenesis of TLS and HD MTX–associated toxicity, to understand the mechanism of action of these therapeutic agents and to review the currently available evidence supporting their use.

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来源期刊

Seminars in nephrology 医学-泌尿学与肾脏学

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Seminars in Nephrology is a timely source for the publication of new concepts and research findings relevant to the clinical practice of nephrology. Each issue is an organized compendium of practical information that serves as a lasting reference for nephrologists, internists and physicians in training.