[鄂木斯克州居民叶酸循环障碍相关疾病风险形成过程中营养和遗传决定因素的作用评估]。

Q2 Medicine
Voprosy pitaniia Pub Date : 2023-01-01 Epub Date: 2023-03-01 DOI:10.33029/0042-8833-2023-92-2-35-42
E A Vilms, D V Turchaninov, I V Antonova, O V Kozubenko
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引用次数: 0

摘要

叶酸循环涉及多种必需营养素,其有效性取决于这些营养素的充足摄入。此外,亚甲基四氢叶酸还原酶(MTHFR)、蛋氨酸合成酶还原酶(MTRR)和蛋氨酸合成酶(MTR)基因的多态变异会影响叶酸循环的一系列生化反应,也应被视为一些疾病发病的风险因素。本研究的目的就是研究这些风险因素的流行情况。材料和方法叶酸循环基因多态性的流行情况:研究了鄂木斯克地区成人随机分层抽样(按性别和年龄)[n=139,51 名男性,88 名女性,年龄 18 至 75 岁,中位年龄 37(26;48)岁]的 MTHFR 基因 C677T 多态性和 MTRR 基因 A66G 多态性。多态性的鉴定是通过等位基因特异性聚合酶链反应方法和电泳检测方案进行的。通过食物摄入频率问卷,确定了叶酸循环所涉及的营养素的膳食摄入量:对鄂木斯克地区具有代表性的分层抽样居民进行了 B 族维生素(B6、B2、B9、B12)、蛋氨酸、胆碱的测定[n=421,男性 177 人,女性 244 人,年龄 18-83 岁,中位年龄 37(23;57)岁]。结果。MTHFR 基因型(A222V С677T C>T)分布如下:CC型--51.3%,CT型--41.0%,TT型--7.7%;MTRR基因型(I22M A>G):AA型--57.9%,AG型--30.3%,GG型--11.8%。对实际营养状况的分析表明,88.2%的人叶酸摄入量低于建议膳食摄入量,40.5%的人维生素 B2 和胆碱摄入量低于建议膳食摄入量,29.2%的人维生素 B6 摄入量低于建议膳食摄入量,22.0%的人蛋氨酸摄入量低于建议膳食摄入量。维生素 B12 的摄入量在建议范围内。结论所提供的全部数据表明,各种因素的综合影响和广泛分布决定了叶酸循环的低效率,因此,该地区的成年人患特征性病症的风险很高,这就决定了采取包括健康营养在内的预防措施的必要性和优先性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Assessment of the role of nutritional and genetic determinants in the formation of the risk of diseases associated with folate cycle disorders in the population of the Omsk region].

A number of essential nutrients are involved in the folate cycle, and its effectiveness depends on the sufficient intake of them. In addition, polymorphic variants of the methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR) and methionine synthase (MTR) genes affect a wide range of biochemical reactions of the folate cycle and should also be considered as a risk factor for the development of a number of diseases. The purpose of this research was to study the prevalence of these risk factors. Material and methods. The prevalence of polymorphisms of the folate cycle genes: C677T polymorphism of the MTHFR gene and A66G polymorphism of the MTRR gene in a random stratified (by sex and age) sample of the adult population of the Omsk region [n=139, 51 men, 88 women, aged 18 to 75 years, median age 37 (26; 48) years] was studied. The identification of polymorphisms was carried out by the method of allele-specific polymerase chain reaction with an electrophoretic detection scheme. Using the food intake frequency questionnaire, the dietary intake of nutrients involved in the folate cycle was determined: B vitamins (B6, B2, B9, B12), methionine, choline, in a representative stratified sample of residents of the Omsk region [n=421, 177 men, 244 women, aged 18 to 83 years, median age 37 (23; 57) years]. Results. MTHFR genotypes (A222V С677T C>T) were distributed as follows: CC-type - 51.3%, CT - 41.0%, TT - 7.7%; MTRR genotypes (I22M A>G): AA type - 57.9%, AG - 30.3%, GG - 11.8%. The analysis of actual nutrition showed consumption below the recommended dietary intake of folates in 88.2% persons, vitamin B2 and choline - in 40.5%, vitamin B6 - in 29.2%, methionine - in 22.0%. Vitamin B12 intake was within the recommended range. Conclusion. The totality of the data presented indicates the combined influence and wide distribution of factors that determine the low efficiency of the folate cycle, and, as a result, a high risk of developing a characteristic pathology for the adult population of the region, which determines the need and priorities for prevention measures, including healthy nutrition.

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Voprosy pitaniia
Voprosy pitaniia Medicine-Medicine (all)
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