Aneta Pekáčová, Jiří Baloun, Xiao Švec, Ladislav Šenolt
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引用次数: 2
摘要
骨关节炎(OA)是一种常见的肌肉骨骼疾病，影响着全世界数百万人。尽管对OA发病机制的了解有所进展，但目前还没有预后生物标志物或有效的靶向治疗方法。随着检测表观遗传因子的新技术的不断出现，表观遗传因子的研究产生了一些新的见解。在这种情况下，非编码rna，包括微rna、长链非编码rna、环状rna、piwi相互作用rna和小核核rna，调节细胞内信号通路和生物过程，在多种疾病的发展中起着至关重要的作用。在这篇综述中，我们介绍了目前表观遗传因素的作用，重点是非编码rna在OA的发生、预测和治疗中的作用。本文分类为:RNA in Disease and Development > RNA in Disease。
Non-coding RNAs in diseases with a focus on osteoarthritis.
Osteoarthritis (OA) is a frequent musculoskeletal disorder affecting millions of people worldwide. Despite advances in understanding the pathogenesis of OA, prognostic biomarkers or effective targeted treatment are not currently available. Research on epigenetic factors has yielded some new insights as new technologies for their detection continue to emerge. In this context, non-coding RNAs, including microRNAs, long non-coding RNAs, circular RNAs, piwi-interacting RNAs, and small nucleolar RNAs, regulate intracellular signaling pathways and biological processes that have a crucial role in the development of several diseases. In this review, we present current knowledge on the role of epigenetic factors with a focus on non-coding RNAs in the development, prediction and treatment of OA. This article is categorized under: RNA in Disease and Development > RNA in Disease.
期刊介绍：
WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
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