猪磷灰石异种移植物上颌窦底扩大术:一项前瞻性病例系列研究。

IF 1.3 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE
Carlo Maria Soardi, Francesco Cavani, Barbara Soardi, Davide Zaffe, Hom-Lay Wang
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引用次数: 0

摘要

本研究在临床和组织学上评估了用于抬高严重萎缩的上颌窦嵴中上颌窦底的猪骨异种移植物的结果。对24例冠骨≤2mm的患者进行了两阶段的冠窗窦抬高方案。在抬高的窦腔内放置用盐水润湿的高多孔猪碳酸磷灰石作为唯一的移植材料。在鼻窦扩大术后6、9和12个月(植入时)采集骨芯活检样本。使用microCT(μCT)和组织学分析评估治疗结果。统计分析采用非参数Kruskal-Wallis检验,然后采用事后Dunn多重比较检验。植入后6个月,所有植入物均达到良好的初始稳定性(插入扭矩≥30Ncm),并成功实现骨整合。移植物残留量(平均值±SE)在6个月时较低(11.91%±1.99%),到12个月时进一步下降(6.11%±2.64%)。相反,6个月时检测到的新骨数量为18.94%±4.08%,12个月时显著增加(P<0.05)(40.16%±5.27%)。组织学评估显示破骨细胞积极吸收移植物,成骨细胞积极形成新骨。在严重萎缩的上颌骨中,猪磷灰石异种移植物在缓慢吸收的同时促进新骨的形成。在有限的样本量范围内,猪磷灰石异种移植物似乎是一种很好的种植材料,可用于种植冠窗窦。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Maxillary Sinus Floor Augmentation with Porcine-Apatite Xenograft: A Prospective Case Series Study.

This study clinically and histologically evaluated the outcome of a porcineapatite xenograft used to elevate the maxillary sinus floor in a severely atrophic ridge. A two-stage crestal window sinus elevation protocol was conducted in 24 patients with crestal bone ≤ 2 mm. Highly porous porcine carbonate apatite moistened with saline solution was placed in the elevated sinus cavity as the sole grafting material. Bone core biopsy samples were taken at 6, 9, and 12 months after sinus augmentation surgery (at implant placement). Treatment outcomes were assessed using microCT (μCT) and histologic analysis. Statistical analysis was performed using nonparametric Kruskal-Wallis test, followed by post-hoc Dunn multiple comparison test. At 6 months after implant placement, all implants achieved good primary stability (insertion torque ≥ 30 Ncm) and successfully osseointegrated. The residual graft amount (mean ± SE) was low (11.91% ± 1.99%) at 6 months and further decreased (6.11% ± 2.64%) by 12 months. On the contrary, the amount of new bone detected was 18.94% ± 4.08% at 6 months and was significantly (P < .05) increased (40.16% ± 5.27%) at 12 months. Histologic assessment revealed osteoclasts actively resorbing the graft as well as osteoblasts actively forming new bone. In the severely atrophic maxilla, the porcine-apatite xenograft promotes new bone formation while being slowly absorbed. Within the limited sample size, the porcine-apatite xenograft seems to be a good graft material for crestal window sinus augmentation.

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来源期刊
CiteScore
2.90
自引率
6.20%
发文量
113
审稿时长
6-12 weeks
期刊介绍: The International Journal of Periodontics & Restorative Dentistry will publish manuscripts concerned with all aspects of clinical periodontology, restorative dentistry, and implantology. This includes pertinent research as well as clinical methodology (their interdependence and relationship should be addressed where applicable); proceedings of relevant symposia or conferences; and quality review papers. Original manuscripts are considered for publication on the condition that they have not been published or submitted for publication elsewhere.
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