儿童、青少年和年轻人成熟b细胞淋巴瘤的诊断和治疗

IF 2.2 4区医学 Q3 HEMATOLOGY

Best Practice & Research Clinical Haematology Pub Date : 2023-06-01 DOI:10.1016/j.beha.2023.101463

Stanton Goldman , Mitchell S. Cairo

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引用次数: 0

摘要

儿童、青少年和年轻人的成熟B细胞淋巴瘤包括三种主要的组织学亚型，按频率顺序包括Burkitt、生发中心弥漫性大B细胞淋巴瘤和原发性纵隔B细胞淋巴瘤。在资源丰富的国家，根据临床分组，前两种激进短期化疗的治愈率为~90%。最近的数据表明，免疫治疗的结合提高了晚期患者的无事件生存率。未来的研究将探讨通过替代免疫疗法来减轻化疗负担的可能性。

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Diagnosis and management of mature B-cell lymphomas in children, adolescents, and young adults

Mature B-cell lymphoma in children, adolescents and young adults comprises three major histological subtypes including in order of frequency Burkitt, germinal center diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma. The cure rate of the first two with aggressive short chemotherapy based on clinical grouping is ∼90% in resource rich countries. Recent data has shown that incorporation of immune therapy has enhanced event free survival in advanced patients. Future studies will address the possibility of reducing the burden of chemotherapy by substitution of immune based therapies.

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来源期刊

Best Practice & Research Clinical Haematology 医学-血液学

CiteScore

4.20

自引率

0.00%

发文量

审稿时长

35 days

期刊介绍： Best Practice & Research Clinical Haematology publishes review articles integrating the results from the latest original research articles into practical, evidence-based review articles. These articles seek to address the key clinical issues of diagnosis, treatment and patient management. Each issue follows a problem-orientated approach which focuses on the key questions to be addressed, clearly defining what is known and not known, covering the spectrum of clinical and laboratory haematological practice and research. Although most reviews are invited, the Editor welcomes suggestions from potential authors.