人参水醇提取物和氨苄青霉素治疗单核细胞增多性李斯特菌诱导的心内膜炎动物模型的效果。

IF 1.9 Q3 CHEMISTRY, MEDICINAL
Seyed Zanyar Athari, Zahra Karamouz, Mir Alireza Nourazar, Yousef Doustar, Younes Anzabi
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引用次数: 0

摘要

目的:心内膜炎是由单核细胞增多性李斯特菌引起的一种罕见但严重的感染。人参在早期的研究中显示出多种免疫调节作用。众所周知,氨苄青霉素是治疗这种疾病的有效抗生素。因此,本研究旨在评估人参水醇提取物和氨苄青霉素治疗单核细胞增多性李斯特菌诱导的心内膜炎动物模型的效果。材料和方法:30只5-7周龄的小鼠随机分为5组(n=6),包括健康对照组、感染组、氨苄青霉素(20mg/kg,皮下)治疗组、人参(0.025mg/kg,腹膜内)治疗组和人参(0.025 mg/kg,腹腔内)+氨苄青霉素组(15mg/kg,皮下)。测量心脏组织中细胞因子的浓度,如IL-1(白细胞介素-1)、IL-6、IL-8和TNF-α(肿瘤坏死因子-α)。评估心脏组织的组织病理学变化。结果:与其他实验组相比,氨苄青霉素+人参治疗组的细胞因子水平显著降低。显微镜下,心脏组织的病理变化伴随着生化结果,在感染组中,可以检测到心内膜组织中的中性粒细胞和单核细胞浸润、心肌细胞坏死和水肿。与正常对照组相比,氨苄青霉素+人参组没有显示出显著的变化。结论:人参水醇提取物联合氨苄青霉素对李斯特菌病引起的实验性心内膜炎有较好的疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Effect of hydro-alcoholic extract of <i>Panax ginseng</i> and Ampicillin treatment in an animal model of <i>Listeria monocytogenes</i>-induced endocarditis.

Effect of hydro-alcoholic extract of <i>Panax ginseng</i> and Ampicillin treatment in an animal model of <i>Listeria monocytogenes</i>-induced endocarditis.

Effect of hydro-alcoholic extract of <i>Panax ginseng</i> and Ampicillin treatment in an animal model of <i>Listeria monocytogenes</i>-induced endocarditis.

Effect of hydro-alcoholic extract of Panax ginseng and Ampicillin treatment in an animal model of Listeria monocytogenes-induced endocarditis.

Objective: Endocarditis is a rare but serious infection caused by Listeria monocytogenes. Panax ginseng demonstrated multiple immunomodulatory effects in earlier studies. Ampicillin is known as an effective antibiotic in the treatment of this disease. Therefore, this study aimed to evaluate the effect of hydro-alcoholic extract of P. ginseng and ampicillin treatment in an animal model of Listeria monocytogenes-induced endocarditis.

Materials and methods: Thirty mice, 5-7 weeks old, were randomly divided into five groups (n=6) including Healthy Control, Infected, Ampicillin (20 mg/kg, subcutaneous) treatment, Ginseng (0.025 mg/kg, intraperitoneal) treatment, and Ginseng (0.025 mg/kg, intraperitoneal) +Ampicillin (15 mg/kg, subcutaneous) treatment groups. The concentration of cytokines in heart tissue, such as IL-1 (interleukine-1), IL-6, IL-8, and TNF-α (Tumor Necrosis Factor-α), was measured. Histopathological changes were evaluated in heart tissues.

Results: The levels of cytokines were significantly decreased in the Ampicillin+Ginseng treated group compared to the other experimental groups. Microscopically, pathologic changes in heart tissue were concomitant with biochemical findings, which in the infected group, neutrophils and mononuclear cells infiltration in endocardial tissue, myocardial cell necrosis, and edema were detectable. The Ampicillin+Ginseng group showed no significant changes compared to the normal control group.

Conclusion: This study showed that ginseng hydro-alcoholic extract plus ampicillin has better efficacy than the extract or antibiotic alone against experimental endocarditis caused by Listeriosis.

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来源期刊
Avicenna Journal of Phytomedicine
Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-
CiteScore
3.40
自引率
4.50%
发文量
17
审稿时长
6 weeks
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