复发性岩膜瘤:脑膜瘤还是孤立性纤维瘤?]

Q4 Medicine
E V Prozorenko, V B Karakhan, O P Bliznyukov, N V Sevyan
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引用次数: 0

摘要

颅内脑膜孤立性纤维性肿瘤(SFT)起源于间质组织,远比内脏胸膜或肝脏病变少见,仅在1996年作为一种分科形式被分离出来。这些肿瘤在临床表现、MRI和光镜数据上与脑膜瘤相同。根据WHO第5版分类,SFT的病理差异在于STAT6基因编码蛋白的过表达检测。其他免疫组织化学标志物的估计是可变的。同时,SFT有更频繁复发和迟发性恶性肿瘤的趋势。过渡形式是可能的。为了形成更清晰的SFT的病分学轮廓,有必要积累临床观察。一个巨大的脑膜瘤的后颅窝,其复发后的18年,在5年的控制,完全切除,提出。原发和复发肿瘤的光镜检查显示纤维性脑膜瘤(WHO GI)。免疫组织化学显示CD34和CD99弥漫性过表达。测定STAT6蛋白的表达在技术上是不可能的。本病例为颞骨锥体后表面脑膜瘤,生长进入第四脑室腔,晚期复发无恶性,具有特异性免疫组化特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Recurrent petrosal tumor: meningioma or solitary fibrous tumor?]

Intracranial meningeal solitary fibrous tumors (SFT) originating from mesenchymal tissue are much less common than those with lesions of the visceral pleura or liver and were isolated as a nosological form only in 1996. These tumors are identical in clinical manifestations, MRI and light microscopy data to meningiomas. The pathognomonic difference of SFT, according to the 5th edition of the WHO classification, is the detection of overexpression of the protein encoded by the STAT6 gene. Estimation of other immunohistochemical markers is variable. At the same time, SFT has a tendency to more frequent recurrence and delayed malignancy. Transitional forms are possible. To form a clearer nosological outline of the SFT, it is necessary to accumulate clinical observations. A case of a giant meningioma of the posterior cranial fossa, which recurred 18 years after total removal at a 5-year annual control, is presented. Light microscopy of both primary and recurrent tumors revealed fibrous meningioma (WHO GI). Immunohistochemically revealed diffuse overexpression of CD34 and CD99. Determining the expression of the STAT6 protein was not technically possible. This case is regarded as a meningioma of the posterior surface of the pyramid of the temporal bone, growing into the cavity of the IV ventricle, with late recurrence without malignancy, with specific immunohistochemical profile.

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来源期刊
Arkhiv patologii
Arkhiv patologii Medicine-Pathology and Forensic Medicine
CiteScore
0.90
自引率
0.00%
发文量
55
期刊介绍: The journal deals with original investigations on pressing problems of general pathology and pathologic anatomy, newest research methods, major issues of the theory and practice as well as problems of experimental, comparative and geographic pathology. To inform readers latest achievements of Russian and foreign medicine the journal regularly publishes editorial and survey articles, reviews of the most interesting Russian and foreign books on pathologic anatomy, new data on modern methods of investigation (histochemistry, electron microscopy, autoradiography, etc.), about problems of teaching, articles on the history of pathological anatomy development both in Russia and abroad.
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