青少年的反社会行为与前顶叶网络效率降低有关。

IF 3.9 2区 医学 Q2 NEUROSCIENCES
Scott Tillem, Hailey L Dotterer, Leigh G Goetschius, Nestor Lopez-Duran, Colter Mitchell, Christopher S Monk, Luke W Hyde
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引用次数: 0

摘要

青少年反社会行为(AB)与社会情感处理、奖赏和威胁处理以及执行功能方面的缺陷有关。这些缺陷被认为源于神经结构、功能和连接的差异,尤其是默认网络、显著性网络和额顶叶网络的差异。然而,AB 与这些网络组织之间的关系仍不清楚。为了填补这一空白,本研究对一组 161 名青少年(95 名女性)的静息态功能磁共振成像数据进行了非加权、非定向图分析,并对贫困这一 AB 风险因素进行了富集。先前的研究表明,"冷酷无情"(CU)特质可能会缓和青少年AB型糖尿病的神经认知特征,因此我们研究了作为调节因素的CU特质。通过使用多formant潜因素,我们发现AB型青少年与效率较低的额顶叶网络拓扑结构有关,而额顶叶网络拓扑结构与执行功能有关。然而,这种影响仅限于CU特质处于低水平或平均水平的青少年,这表明这些神经差异是AB特质高的青少年所特有的,而不是CU特质高的青少年。AB特质、CU特质或它们之间的交互作用都与默认网络拓扑结构或突出网络拓扑结构无明显关系。研究结果表明,AB特质可能与顶叶前部网络结构的变化有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Antisocial behavior is associated with reduced frontoparietal network efficiency in youth.

Antisocial behavior is associated with reduced frontoparietal network efficiency in youth.

Youth antisocial behavior (AB) is associated with deficits in socioemotional processing, reward and threat processing and executive functioning. These deficits are thought to emerge from differences in neural structure, functioning and connectivity, particularly within the default, salience and frontoparietal networks. However, the relationship between AB and the organization of these networks remains unclear. To address this gap, the current study applied unweighted, undirected graph analyses to resting-state functional magnetic resonance imaging data in a cohort of 161 adolescents (95 female) enriched for exposure to poverty, a risk factor for AB. As prior work indicates that callous-unemotional (CU) traits may moderate the neurocognitive profile of youth AB, we examined CU traits as a moderator. Using multi-informant latent factors, AB was found to be associated with less efficient frontoparietal network topology, a network associated with executive functioning. However, this effect was limited to youth at low or mean levels of CU traits, indicating that these neural differences were specific to those high on AB but not CU traits. Neither AB, CU traits nor their interaction was significantly related to default or salience network topologies. Results suggest that AB, specifically, may be linked with shifts in the architecture of the frontoparietal network.

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来源期刊
CiteScore
6.80
自引率
4.80%
发文量
62
审稿时长
4-8 weeks
期刊介绍: SCAN will consider research that uses neuroimaging (fMRI, MRI, PET, EEG, MEG), neuropsychological patient studies, animal lesion studies, single-cell recording, pharmacological perturbation, and transcranial magnetic stimulation. SCAN will also consider submissions that examine the mediational role of neural processes in linking social phenomena to physiological, neuroendocrine, immunological, developmental, and genetic processes. Additionally, SCAN will publish papers that address issues of mental and physical health as they relate to social and affective processes (e.g., autism, anxiety disorders, depression, stress, effects of child rearing) as long as cognitive neuroscience methods are used.
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