丙型肝炎病毒中和的结构见解

IF 5.7 2区医学 Q1 VIROLOGY

Current opinion in virology Pub Date : 2023-06-01 DOI:10.1016/j.coviro.2023.101316

Luisa J. Ströh , Thomas Krey

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引用次数: 1

摘要

尽管有可用的抗病毒治疗，丙型肝炎病毒（HCV）仍然是全球健康负担，预防性疫苗将有助于消除患慢性肝病的风险。对糖蛋白E1和E2在病毒进入中的功能以及与宿主体液免疫反应的相互作用的结构见解是知情疫苗开发的关键。我们综述了最近报道的HCV糖蛋白受体结合和完整膜结合E1–E2异二聚体组装的结构见解。这些数据与可用的功能数据一起用于绘制病毒进入的简化模型，这突出了我们目前知识中的差距，需要进一步研究，以在原子水平上充分了解这一过程。

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Structural insights into hepatitis C virus neutralization

Inspite of the available antiviral therapy, hepatitis C virus (HCV) remains a global health burden and a prophylactic vaccine would help to eliminate the risk to develop chronic liver diseases. Structural insights into the function of the glycoproteins E1 and E2 in virus entry and the interplay with the host’s humoral immune response are key for informed vaccine development. We review recently reported structural insights into receptor binding of HCV glycoproteins and the assembly of an intact membrane-bound E1–E2 heterodimer. These data are used together with available functional data to draw a simplified model of virus entry, which highlights gaps in our current knowledge that warrant further research to fully understand this process at the atomic level.

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来源期刊

Current opinion in virology VIROLOGY-

CiteScore

11.80

自引率

5.10%

发文量

审稿时长

83 days

期刊介绍： Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.