你们使用哪种c肽测定法?描述c肽测定性能的需求日益增加。

Q3 Medicine
Pim Dekker, Martine de Vries, Henk-Jan Aanstoot, Joost Groen
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引用次数: 0

摘要

许多c肽测定法在商业上可用于研究和常规使用。然而,并不是所有的分析都产生一致的结果,特别是在低浓度范围内。我们检索了描述c肽测量的文献,以评估哪些检测主要用于糖尿病研究领域,以及它们是否被指定。关于1型糖尿病(T1D)、2型糖尿病(T2D)和其他形式糖尿病中c肽测量的出版物比例分别为32%、54%和14%。在只有54%的出版物中指定了使用的检测方法。检出限、测量范围和变异的信息分别在12%、2%和11%的出版物中提供。22%的出版物没有提到c肽浓度。这可能是一个问题,特别是在T1D研究中,测量非常低水平的c肽变得越来越重要,而且检测之间的一致性很低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Which C-peptide assay do you use? Increasing need for describing C-peptide assay performance.

Which C-peptide assay do you use? Increasing need for describing C-peptide assay performance.

Which C-peptide assay do you use? Increasing need for describing C-peptide assay performance.

Many C-peptide assays are commercially available for research and routine use. However, not all assays yield consistent results, especially in the low concentration ranges. We searched the literature describing C-peptide measurements to assess which assays are mainly used in the diabetes research field and if they are specified. Percentages of publications on C-peptide measurements in type 1 diabetes (T1D), type 2 diabetes (T2D) and other forms of diabetes were 32%, 54% and 14%, respectively. In only 54% of the publications the used assay was specified. Information on detection limit, measurement range and variation was provided in 12%, 2% and 11% of publications, respectively. In 22% of all publications no C-peptides concentrations were mentioned. This may be a problem especially for T1D research, where measuring very low levels of C-peptide is becoming increasingly important and concordance between assays is low.

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来源期刊
Pediatric Endocrinology, Diabetes and Metabolism
Pediatric Endocrinology, Diabetes and Metabolism Medicine-Pediatrics, Perinatology and Child Health
CiteScore
2.00
自引率
0.00%
发文量
36
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