血清尿酸与高密度脂蛋白胆固醇比值升高与糖尿病肾损伤有关吗?

IF 2.6 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Gulali Aktas, Seyma Yilmaz, Didar Beyza Kantarci, Tuba Taslamacioglu Duman, Satilmis Bilgin, Sumeyye Buse Balci, Burcin Meryem Atak Tel
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引用次数: 21

摘要

目的:糖尿病性肾损伤(DKI)是2型糖尿病(T2DM)的一种严重微血管并发症。人们正在开发新的标志物来及时诊断这种并发症。尿酸与高密度脂蛋白比值(UHR)与代谢综合征、2型糖尿病、甲状腺炎和非酒精性肝纤维化等炎性和代谢性疾病有关。在本研究中,我们旨在展示UHR糖尿病肾损伤(DKI)的诊断作用,DKI是一种以慢性低度炎症为特征的疾病。方法:回顾性分析我院门诊287例t2min患者的资料。根据DKI的存在将研究人群分为两组。将合并DKI的糖尿病患者与未合并DKI的糖尿病患者的一般特征和实验室数据(包括UHR水平)进行比较。结果:糖尿病合并DKI组的UHR中位数(0.13(0,06-0,33))显著高于未合并DKI组的UHR中位数(0.11 (0,04-0,34))(p p=0.02)、血清肌酐(r=0.18, p=0.002)和糖化血红蛋白(r=0.28, pp=0.001)。逻辑回归分析证实,UHR每增加0.1个点,DKI的几率就会增加2.3倍。UHR还与血清肌酐、GFR和UACR相关,这是DKI的重要标志。结论:根据本研究的初步结果,我们认为UHR可作为糖尿病肾损伤的诊断工具。UHR在DKI中具有独立的预测作用,并且与其他肾功能指标有显著的相关性,因此,我们建议在dki患者中常规评估UHR以及其他指标,如血清肌酐、GFR和UACR。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Is serum uric acid-to-HDL cholesterol ratio elevation associated with diabetic kidney injury?

Objectives: Diabetic kidney injury (DKI) is a serious microvascular complicationof type 2 diabetes mellitus (T2DM). Novel markers are being developedto make a timely diagnosis of this complication. Uric Acid to HDLratio (UHR) was reported to be associated with inflammatory andmetabolic diseases such as metabolic syndrome, type 2 diabetesmellitus, thyroiditis, and nonalcoholic hepatosteatosis, recently. Inthe present study, we aimed to show the diagnostic role of UHR indiabetic kidney injury (DKI), a condition characterized with chronicand low-grade inflammation.

Methods: We retrospectively analyzed data of 287 patients who already had T2D Min outpatient clinics of our institution. The study population was divided into two groups according to the presence of DKI. General characteristics and laboratory data, including UHR levels, of the diabetic subjects with DKI were compared to those of patients without DKI.

Results: The median UHR of the diabetic patients with DKI group (0,13 (0,06-0,33)) was significantly elevated compared to the UHR of diabetic patients without DKI (0,11 (0,04-0,34)) (p < 0.001). Median UHR was significantly and positively correlated with UACR (r=0.14, p=0.02), serum creatinine (r=0.18, p=0.002), and HbA1c (r=0.28, p<0.001) levels. There was also a significant inverse correlation between UHR and GFR (r=-0.19, p=0.001) values. Logistic regression analysis confirmed that a 0.1 point increase in UHR increases DKI odds by 2.3 times. UHR was also correlated with serum creatinine, GFR, and UACR, which are important signs for DKI.

Conclusion: In conclusion, we think that UHR could be a diagnostic tool indiabetic kidney injury according to the preliminary results of the present study. UHR has an independent predictive role in DKI, and ithas significant correlation with other markers of kidney functions, therefore, we suggest routine evaluation of UHR in patients with DKIalong with other markers such as serum creatinine, GFR, and UACR.

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来源期刊
Postgraduate Medicine
Postgraduate Medicine 医学-医学:内科
CiteScore
6.10
自引率
2.40%
发文量
110
审稿时长
6-12 weeks
期刊介绍: Postgraduate Medicine is a rapid peer-reviewed medical journal published for physicians. Tracing its roots back to 1916,  Postgraduate Medicine  was established by Charles Mayo, MD, as a peer-to-peer method of communicating the latest research to aid physicians when making treatment decisions, and it maintains that aim to this day. In addition to its core subscriber base, Postgraduate Medicine is distributed to hundreds of US-based physicians within internal medicine and family practice.
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