危重肺狭窄新生儿先天性纤原蛋白血症的治疗。

Q2 Medicine

Journal of Pediatric Pharmacology and Therapeutics Pub Date : 2023-01-01 DOI:10.5863/1551-6776-28.3.268

Priya Parikh, Kimvi Diep, Vinod Balasa, Tiffany L Lucas

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引用次数: 0

摘要

新生儿纤维蛋白原缺乏可导致出血并发症。在这个报告中，我们描述了一个先天性纤原蛋白血症的新生儿重症肺狭窄谁提出了双侧脑血肿后，一个简单的分娩。最初使用低温沉淀，随后给予纤维蛋白原浓缩物。我们估计浓缩产品的半衰期为24至48小时。该患者接受了纤维蛋白原置换，随后心脏修复成功。该药物在该新生儿中的半衰期较短，与先前报道的老年患者的半衰期较长形成对比，这在治疗未来患有该诊断的新生儿患者时值得注意。

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Treatment of Congenital Afibrinogenemia in a Neonate With Critical Pulmonary Stenosis.

Fibrinogen deficiencies in neonates can lead to bleeding complications. In this report, we describe a case of congenital afibrinogenemia in a newborn with critical pulmonary stenosis who presented with bilateral cephalohematomas after an uncomplicated delivery. The initial use of cryoprecipitate was followed by administration of fibrinogen concentrate. We estimated a half-life of 24 to 48 hours with the concentrate product. This patient received fibrinogen replacement and had a subsequent successful cardiac repair. The drug's shorter half-life in this neonate contrasts with prior reports of longer half-life in older patients and is important to note in treating future neonatal patients with this diagnosis.

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来源期刊

Journal of Pediatric Pharmacology and Therapeutics Medicine-Pediatrics, Perinatology and Child Health

CiteScore

2.40

自引率

0.00%

发文量

期刊介绍： The Journal of Pediatric Pharmacology and Therapeutics is the official journal of the Pediatric Pharmacy Advocacy Group. JPPT is a peer-reviewed multi disciplinary journal that is devoted to promoting the safe and effective use of medications in infants and children. To this end, the journal publishes practical information for all practitioners who provide care to pediatric patients. Each issue includes review articles, original clinical investigations, case reports, editorials, and other information relevant to pediatric medication therapy. The Journal focuses all work on issues related to the practice of pediatric pharmacology and therapeutics. The scope of content includes pharmacotherapy, extemporaneous compounding, dosing, methods of medication administration, medication error prevention, and legislative issues. The Journal will contain original research, review articles, short subjects, case reports, clinical investigations, editorials, and news from such organizations as the Pediatric Pharmacy Advocacy Group, the FDA, the American Academy of Pediatrics, the American Society of Health-System Pharmacists, and so on.