成年女性子宫胚胎性横纹肌肉瘤:1例具有挑战性的诊断和治疗。

IF 1.2 4区 医学 Q4 DEVELOPMENTAL BIOLOGY
Cătălin Florin Pop, Claudia Maria Stanciu-Pop, Christiane Jungels, Marie Chintinne, Carlos Artigas Guix, Florin Grosu, Ciprian Juravle, Isabelle Veys
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引用次数: 0

摘要

背景:子宫胚胎性横纹肌肉瘤(uERMS)发生于成年女性是一种非常罕见的恶性肿瘤。本研究报告1例成人uERMS,并讨论组织病理学诊断对治疗及预后的影响。病例介绍:我们在此报告一名成年女性的uERMS病例的临床病理特征。该研究已获得机构伦理委员会的批准,并已获得知情同意(IJB / CE3005)。一位45岁女性因月经间出血和宫颈息肉样肿块(最初解释为良性息肉)就诊于妇科医生。第二次活检被送到我们位于比利时布鲁塞尔的Jules bordt研究所的病理学部门进行修改,并被重新解释为botryid型uERMS。病人接受了全子宫切除术。最终病理证实3厘米宫颈ERMS,我们的多学科团队决定进行简单的监测。6个月后,盆腔磁共振成像显示右侧盆腔淋巴结复发。手术前行多药化疗和放疗。病理检查证实盆腔肿块复发60 mm,伴有大面积坏死和软骨结构。病人在诊断后60个月无病。结论:成人uERMS罕见,病理检查是诊断和治疗的主要依据。它经常与其他良性实体混淆,至少在诊断时是这样。成年女性宫颈和子宫息肉的鉴别诊断应纳入ERMS检查。通过多模式治疗,长期生存是可能的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Uterine embryonal rhabdomyosarcoma in adult women: a case report on the challenging diagnosis and treatment.

Uterine embryonal rhabdomyosarcoma in adult women: a case report on the challenging diagnosis and treatment.

Uterine embryonal rhabdomyosarcoma in adult women: a case report on the challenging diagnosis and treatment.

Background: Uterine embryonal rhabdomyosarcoma (uERMS) in adult women is a very rare malignant entity. The study aim was to report a case of adult uERMS and to discuss the implications of histopathological diagnosis on the treatment and prognosis.

Case presentation: We present here the clinicopathological features of a uERMS case in an adult woman. The study has been approved by the institutional Ethics Committee and an informed consent has been obtained (IJB∕CE3005). A 45-year-old woman presented to her gynecologist with intermenstrual bleedings and polypoid cervical mass (initially interpreted as benign polyp). A second biopsy was sent to our Department of Pathology at the Jules Bordet Institute, Brussels, Belgium for revision and was reinterpreted as botryoid-type uERMS. The patient underwent a total hysterectomy. The final pathology confirms a 3 cm cervical ERMS, and a simple surveillance was decided by our multidisciplinary team. Six months later, pelvic magnetic resonance imaging control showed a recurrence in the right pelvic lymph nodes. Multi-drug chemotherapy and radiotherapy were done before surgical resection. Pathological examination of the resected pelvic mass confirmed uERMS recurrence of 60 mm, with large zones of necrosis and the presence of cartilaginous structures. The patient is free of disease 60 months after diagnosis.

Conclusions: Adult uERMS is rare and the pathological examination is the main element for diagnosis and treatment. It is often confused with other benign entities, at least at the time of diagnosis. ERMS should be included in the differential diagnosis of cervical and uterine polyp of adult women. Long-term survival is possible with a multimodal therapy approach.

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来源期刊
CiteScore
1.70
自引率
20.00%
发文量
221
审稿时长
3-8 weeks
期刊介绍: Romanian Journal of Morphology and Embryology (Rom J Morphol Embryol) publishes studies on all aspects of normal morphology and human comparative and experimental pathology. The Journal accepts only researches that utilize modern investigation methods (studies of anatomy, pathology, cytopathology, immunohistochemistry, histochemistry, immunology, morphometry, molecular and cellular biology, electronic microscopy, etc.).
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