富对映体2,5-二取代吡咯烷的不对称合成

IF 3.3 Q2 CHEMISTRY, MULTIDISCIPLINARY

ACS Organic & Inorganic Au Pub Date : 2023-03-08 DOI:10.1021/acsorginorgau.2c00061

Yanis Lazib, Junio Guimaraes Naves, Agnès Labande, Philippe Dauban* and Tanguy Saget*,

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引用次数: 2

摘要

C2对称支架是金属催化中的特权配体，也广泛应用于有机催化中。其中，2，5-二取代吡咯烷具有极其重要的意义，特别是因为它们在药物化学中也有应用。这篇综述着重介绍了这些C2对称氮杂环的立体选择性合成。它包括基于手性池的使用的合成策略，以及在不对称催化方面取得重大成就后设计的最新序列。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Asymmetric Syntheses of Enantioenriched 2,5-Disubstituted Pyrrolidines

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Asymmetric Syntheses of Enantioenriched 2,5-Disubstituted Pyrrolidines

C₂-Symmetrical scaffolds are privileged ligands in metal catalysis and are also widely used in organocatalysis. Among these, 2,5-disubstituted pyrrolidines hold a paramount importance, especially since they also find application in medicinal chemistry. This review highlights the stereoselective syntheses of these C₂-symmetrical nitrogen heterocycles. It includes synthetic strategies based on the use of the chiral pool as well as the more recent sequences designed following major achievements in asymmetric catalysis.

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来源期刊

ACS Organic & Inorganic Au 有机化学、无机化学-

CiteScore

4.10

自引率

0.00%

发文量

期刊介绍： ACS Organic & Inorganic Au is an open access journal that publishes original experimental and theoretical/computational studies on organic organometallic inorganic crystal growth and engineering and organic process chemistry. Short letters comprehensive articles reviews and perspectives are welcome on topics that include:Organic chemistry Organometallic chemistry Inorganic Chemistry and Organic Process Chemistry.