患者ipscs衍生的神经元和脑类器官。

Q1 Pharmacology, Toxicology and Pharmaceutics

Handbook of experimental pharmacology Pub Date : 2023-01-01 DOI:10.1007/164_2023_657

Wanying Zhu, Lei Xu, Xinrui Li, Hao Hu, Shuning Lou, Yan Liu

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引用次数: 1

摘要

诱导多能干细胞(Induced pluripotent stem cells, iPSCs)在体外通过添加诱导因子和小分子可以分化为特定的神经元和脑类器官，这些细胞携带人类遗传信息，概括了人类大脑的发育过程以及生理、病理和药理特征。因此，ipsc衍生的神经元和类器官在体外研究人类大脑发育和相关神经系统疾病方面具有很大的前景，并为药物筛选提供了平台。本章综述了iPSCs分化神经元和脑类器官技术的发展及其在脑疾病研究、药物筛选和移植等方面的应用。

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iPSCs-Derived Neurons and Brain Organoids from Patients.

Induced pluripotent stem cells (iPSCs) can be differentiated into specific neurons and brain organoids by adding induction factors and small molecules in vitro, which carry human genetic information and recapitulate the development process of human brain as well as physiological, pathological, and pharmacological characteristics. Hence, iPSC-derived neurons and organoids hold great promise for studying human brain development and related nervous system diseases in vitro, and provide a platform for drug screening. In this chapter, we summarize the development of the differentiation techniques for neurons and brain organoids from iPSCs, and their applications in studying brain disease, drug screening, and transplantation.

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来源期刊

Handbook of experimental pharmacology Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

5.20

自引率

0.00%

发文量

期刊介绍： The Handbook of Experimental Pharmacology is one of the most authoritative and influential book series in pharmacology. It provides critical and comprehensive discussions of the most significant areas of pharmacological research, written by leading international authorities. Each volume in the series represents the most informative and contemporary account of its subject available, making it an unrivalled reference source.