腺苷信号在条件调节技术心脏保护机制中的无尽旅程:临床证据。

IF 2.4 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Kuldeep Kumar, Nirmal Singh, Harlokesh Narayan Yadav, Leonid Maslov, Amteshwar Singh Jaggi
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引用次数: 0

摘要

心肌缺血性损伤是各种心血管疾病死亡的主要原因。这种情况的发生是由于心肌的血液和重要营养物质(正常细胞活动和生存能力所必需的)供应中断,最终导致损伤。缺血组织血液供应的恢复会导致更致命的再灌注损伤。已经开发了各种策略,包括一些预处理和后处理技术,以检查再灌注损伤的有害影响。许多内源性物质被认为是这些条件调节技术的起始物、介质和末端效应物。腺苷、缓激肽、乙酰胆碱、血管紧张素、去甲肾上腺素、阿片类药物等物质已被报道可介导心脏保护活性。在这些药物中,腺苷已被广泛研究,并被认为具有最显著的心脏保护作用。目前的综述文章强调腺苷信号在条件反射技术的心脏保护机制中的作用。这篇文章还深入了解了各种临床研究,这些研究证实了腺苷作为心脏保护剂在心肌再灌注损伤中的适用性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Endless Journey of Adenosine Signaling in Cardioprotective Mechanism of Conditioning Techniques: Clinical Evidence.

Myocardial ischemic injury is a primary cause of death among various cardiovascular disorders. The condition occurs due to an interrupted supply of blood and vital nutrients (necessary for normal cellular activities and viability) to the myocardium, eventually leading to damage. Restoration of blood supply to ischemic tissue is noted to cause even more lethal reperfusion injury. Various strategies, including some conditioning techniques, like preconditioning and postconditioning, have been developed to check the detrimental effects of reperfusion injury. Many endogenous substances have been proposed to act as initiators, mediators, and end effectors of these conditioning techniques. Substances, like adenosine, bradykinin, acetylcholine, angiotensin, norepinephrine, opioids, etc., have been reported to mediate cardioprotective activity. Among these agents, adenosine has been widely studied and suggested to have the most pronounced cardioprotective effects. The current review article highlights the role of adenosine signaling in the cardioprotective mechanism of conditioning techniques. The article also provides an insight into various clinical studies that substantiate the applicability of adenosine as a cardioprotective agent in myocardial reperfusion injury.

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来源期刊
Current Cardiology Reviews
Current Cardiology Reviews CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
3.70
自引率
10.50%
发文量
117
期刊介绍: Current Cardiology Reviews publishes frontier reviews of high quality on all the latest advances on the practical and clinical approach to the diagnosis and treatment of cardiovascular disease. All relevant areas are covered by the journal including arrhythmia, congestive heart failure, cardiomyopathy, congenital heart disease, drugs, methodology, pacing, and preventive cardiology. The journal is essential reading for all researchers and clinicians in cardiology.
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