左乙拉西坦对妊娠白化大鼠及其后代的形态学、生物化学和组织病理学影响

IF 1.1 4区 医学 Q4 MICROSCOPY
Ultrastructural Pathology Pub Date : 2023-07-04 Epub Date: 2023-05-03 DOI:10.1080/01913123.2023.2185719
Safaa M H Abdelaziz, Ranya Mohammed Abdelgalil, Shaimaa R Abdelmohsen
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引用次数: 0

摘要

治疗癫痫最广泛使用的药物之一是广谱抗癫痫药物左乙拉西坦。这项研究旨在评估左乙拉西坦对怀孕大鼠及其后代的体重和肝脏的影响。研究包括在怀孕和哺乳期间对大鼠进行治疗,然后对怀孕大鼠及其后代进行检查。研究人员将 40 只怀孕大鼠分成两组(I 组和 II 组)。每组又分成两个小组(A、B)。I 组大鼠在整个孕期(IA)或整个孕期和产后 15 天(IB)连续灌胃蒸馏水,每天约 1.5 毫升。第二组大鼠在怀孕期间(IIA)或怀孕期间加产后 15 天(IIB)每天灌服 1.5 毫升蒸馏水(含左乙拉西坦)。实验结束后,从成年大鼠身上采集血液样本,记录不同组别的体重,然后对其肝脏进行组织学和形态学分析。左乙拉西坦治疗后,成年大鼠及其后代的体重下降,肝脏出现病理变化。这些变化表现为肝脏结构变形、细胞质空泡化、核变化以及线粒体肿胀并失去嵴。肝脏中丙氨酸氨基转移酶(ALT)和天门冬氨酸氨基转移酶(AST)水平的变化证明了这些变化。建议在使用左乙拉西坦时持续监测肝功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Morphological, biochemical, and histopathological effects of levetiracetam on pregnant albino rats and their offspring.

One of the most widely used medications for epilepsy is the broad-spectrum antiseizure levetiracetam. The study aimed to evaluate the impact of levetiracetam on the bodyweight and liver of pregnant rats and their offspring. The study involved treating the rats during pregnancy and lactation and then examining the pregnant rats and their offspring. Two groups of 40 pregnant rats were created (I, II). Each group was split up into two smaller groups (A, B). About 1.5 mL/day of distilled water was gavaged to the rats in group I, either continuously throughout pregnancy (IA) or continuously throughout pregnancy and 15 days after delivery (IB). Group II rats received 1.5 ml/day of distilled water (containing levetiracetam) either during pregnancy (IIA) or during pregnancy plus 15 days postpartum (IIB). At the end of the work, blood samples were taken from the adult rats, body weight of different groups were recorded, and then, their liver was subjected for histological and morphometric analysis. Levetiracetam treatment showed reduction in the body weight of adult rats and their offspring and pathological changes in their liver. These changes were in the form of distortion of the hepatic architecture, cytoplasmic vacuolation, nuclear changes, and swollen mitochondria with loss of their cristae. Such changes were proved by alteration in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzyme levels of the liver. It is advised to monitor the liver functions continuously when using levetiracetam.

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来源期刊
Ultrastructural Pathology
Ultrastructural Pathology 医学-病理学
CiteScore
2.00
自引率
10.00%
发文量
40
审稿时长
6-12 weeks
期刊介绍: Ultrastructural Pathology is the official journal of the Society for Ultrastructural Pathology. Published bimonthly, we are the only journal to be devoted entirely to diagnostic ultrastructural pathology. Ultrastructural Pathology is the ideal journal to publish high-quality research on the following topics: Advances in the uses of electron microscopic and immunohistochemical techniques Correlations of ultrastructural data with light microscopy, histochemistry, immunohistochemistry, biochemistry, cell and tissue culturing, and electron probe analysis Important new, investigative, clinical, and diagnostic EM methods.
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