Diopsys®NOVA™定亮度闪烁ERG与Diagnosys®Espion 2™闪烁ERG参数的相关性评价

IF 2.6 4区 医学 Q2 OPHTHALMOLOGY
Jonathan Regenold, Hien Luong Doan, Hashem Ghoraba, Hassan Khojasteh, Jaclyn Joyce Jaclyn Hwang, Negin Yavari, Amir Akhavanrezayat, Ngoc Trong Tuong Than, Anthony Huy Dinh Le, Muhammad Sohail Halim, Quan Dong Nguyen
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This study aimed to investigate whether light-adapted Diopsys® NOVA™ fixed-luminance flicker ffERG magnitude and implicit time (converted from phase) measurements correlate with light-adapted Diagnosys® Espion 2™ flicker ffERG amplitude and implicit time measurements, respectively.</p><p><strong>Methods: </strong>Twelve patients (22 eyes) with various retinal and uveitic diseases underwent light-adapted Diagnosys® Espion 2™ and Diopsys® NOVA™ fixed-luminance flicker testing. Diopsys® magnitude and implicit time (converted from phase) measurements were compared to Diagnosys® amplitude and implicit time measurements, and a Pearson correlation was used to evaluate any existing correlation. Groups were also compared using generalized estimating equations. Bland-Altman plots were utilized to determine agreement between the comparison groups.</p><p><strong>Results: </strong>Age of patients ranged from 14 to 87 years. 58% (n = 7/12) of patients were female. 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引用次数: 0

摘要

目的:Diopsys®NOVA™是一种新型的全视场视网膜电图(ffERG)设备,可以快速测量视网膜电生理功能。诊断®Espion 2™是临床金标准ERG设备。本研究旨在研究光适应性Diopsys®NOVA™固定亮度闪烁ffERG幅度和隐式时间(从相位转换)测量是否分别与光适应性诊断sys®Espion 2™闪烁ffERG幅度和隐式时间测量相关。方法:12例(22只眼)患有各种视网膜和葡萄膜疾病的患者接受了光适应诊断®Espion 2™和Diopsys®NOVA™固定亮度闪烁测试。将Diopsys®幅度和隐式时间(从相位转换)测量结果与诊断sys®幅度和隐式时间测量结果进行比较,并使用Pearson相关性来评估任何存在的相关性。用广义估计方程对各组进行比较。Bland-Altman图用于确定各组之间的一致性。结果:患者年龄14 ~ 87岁。58% (n = 7/12)的患者为女性。结论:光适应Diopsys®NOVA™固定亮度闪烁幅值与诊断sys®闪烁幅度值之间存在统计学上显著的正相关。此外,Diopsys®NOVA™固定亮度闪烁隐式时间(从相位转换)与诊断sys®闪烁隐式时间值之间存在统计学上显著的正相关。这些结果表明,采用非标准缩短国际临床视觉电生理学会(ISCEV) ERG协议的Diopsys®NOVA™模块可以产生可靠的光适应闪烁ffERG测量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Evaluation of correlation between Diopsys® NOVA™ fixed-luminance flicker ERG and Diagnosys® Espion 2™ flicker ERG parameters.

Evaluation of correlation between Diopsys® NOVA™ fixed-luminance flicker ERG and Diagnosys® Espion 2™ flicker ERG parameters.

Purpose: Diopsys® NOVA™ is a novel full-field electroretinography (ffERG) device that can make rapid measurements of retinal electrophysiologic function. Diagnosys® Espion 2™ is a clinical gold-standard ERG device. This study aimed to investigate whether light-adapted Diopsys® NOVA™ fixed-luminance flicker ffERG magnitude and implicit time (converted from phase) measurements correlate with light-adapted Diagnosys® Espion 2™ flicker ffERG amplitude and implicit time measurements, respectively.

Methods: Twelve patients (22 eyes) with various retinal and uveitic diseases underwent light-adapted Diagnosys® Espion 2™ and Diopsys® NOVA™ fixed-luminance flicker testing. Diopsys® magnitude and implicit time (converted from phase) measurements were compared to Diagnosys® amplitude and implicit time measurements, and a Pearson correlation was used to evaluate any existing correlation. Groups were also compared using generalized estimating equations. Bland-Altman plots were utilized to determine agreement between the comparison groups.

Results: Age of patients ranged from 14 to 87 years. 58% (n = 7/12) of patients were female. A significant, positive correlation (r = 0.880, P < 0.001) was observed between magnitude (Diopsys®) and amplitude (Diagnosys®) measurements. Amplitude increases by 6.69 µV for each 1 µV increase in Magnitude (p-value < 0.001). A statistically significant, strong positive correlation was observed between Diopsys® implicit time measurements (converted from phase) and Diagnosys® implicit time measurements (r = 0.814, p-value < 0.001). For each 1 ms increase in Diopsys® implicit time, Diagnosys® implicit time increases by 1.13 ms (p-value < 0.001).

Conclusions: There is a statistically significant positive correlation between light-adapted Diopsys® NOVA™ fixed-luminance flicker amplitude and Diagnosys® flicker magnitude values. Additionally, there is a statistically significant positive correlation between Diopsys® NOVA™ fixed-luminance flicker implicit time (converted from phase) and Diagnosys® flicker implicit time values. These results imply that the Diopsys® NOVA™ module, which utilizes the nonstandard shortened International Society for Clinical Electrophysiology of Vision (ISCEV) ERG protocol, can produce reliable light-adapted flicker ffERG measurements.

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来源期刊
Documenta Ophthalmologica
Documenta Ophthalmologica 医学-眼科学
CiteScore
3.50
自引率
21.40%
发文量
46
审稿时长
>12 weeks
期刊介绍: Documenta Ophthalmologica is an official publication of the International Society for Clinical Electrophysiology of Vision. The purpose of the journal is to promote the understanding and application of clinical electrophysiology of vision. Documenta Ophthalmologica will publish reviews, research articles, technical notes, brief reports and case studies which inform the readers about basic and clinical sciences related to visual electrodiagnosis and means to improve diagnosis and clinical management of patients using visual electrophysiology. Studies may involve animals or humans. In either case appropriate care must be taken to follow the Declaration of Helsinki for human subject or appropriate humane standards of animal care (e.g., the ARVO standards on Animal Care and Use).
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