[心脏淀粉样变性:病例报告]。

Adriana E Viñas-Mendieta, Mario B García-Saavedra
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引用次数: 0

摘要

淀粉样变性是一种由错误折叠蛋白浸润引起的多系统疾病;心脏受累决定了其预后。有几种前体蛋白可导致该病,但只有两种会影响心脏,即克隆免疫球蛋白轻链(AL)和四聚体转甲状腺素(TTR)蛋白。这种疾病诊断不足,晚期患者预后较差。我们介绍了一名老年患者的病例,该患者有进行性心脏和心外表现,实验室和超声心动图标准使我们更接近心脏淀粉样变性的诊断,也使我们能够评估预后。患者病情发展缓慢,最终死亡。病理解剖研究证实了我们的诊断推测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

[Cardiac amyloidosis: a case report].

[Cardiac amyloidosis: a case report].

[Cardiac amyloidosis: a case report].

[Cardiac amyloidosis: a case report].

Amyloidosis is a multisystem disease caused by infiltration of misfolded proteins; cardiac involvement determines its prognosis. There are several types of precursor proteins capable of causing the disease; however, only two affect the heart, clonal immunoglobulin light chains (AL) and tetrameric transthyretin (TTR) protein. It is an underdiagnosed disease and, in late stages, it has a poor prognosis. We present the case of an older adult patient with progressive cardiac and extracardiac manifestations, as well as laboratory and echocardiographic criteria that brought us closer to the diagnosis of cardiac amyloidosis and also allowed us to assess the prognosis. The patient had a torpid evolution with a fatal outcome. The pathological anatomy studies allowed us to confirm our diagnostic presumption.

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