{"title":"白细胞端粒长度与新冠肺炎严重程度之间的关联。","authors":"Ata Mahmoodpoor, Sarvin Sanaie, Maqsoud Eskandari, Nazila Behrouzi, Majid Taghizadeh, Faranak Roudbari, Babak Emamalizadeh, Nasim Sohrabifar, Somayeh Kazeminasab","doi":"10.1186/s43042-023-00415-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Inter-individual variations in the clinical manifestations of SARS-CoV-2 infection are among the challenging features of COVID-19. The known role of telomeres in cell proliferation and immune competency highlights their possible function in infectious diseases. Variability in telomere length is an invaluable parameter in the heterogeneity of the clinical presentation of diseases.</p><p><strong>Result: </strong>In this study, our aim was to investigate the possible association between leukocyte telomere length (LTL) and COVID-19 severity. LTL was measured in 100 patients with moderate and severe forms of COVID-19 using the quantitative PCR (q-PCR) method. Statistical analysis confirmed a strong inverse correlation between relative LTL and COVID-19 severity.</p><p><strong>Conclusions: </strong>These findings suggest that LTL can be a useful parameter for predicting disease severity in patients, as individuals with short telomeres may have a higher risk of developing severe COVID-19.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1186/s43042-023-00415-z.</p>","PeriodicalId":74994,"journal":{"name":"The Egyptian journal of medical human genetics","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225776/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association between leukocyte telomere length and COVID-19 severity.\",\"authors\":\"Ata Mahmoodpoor, Sarvin Sanaie, Maqsoud Eskandari, Nazila Behrouzi, Majid Taghizadeh, Faranak Roudbari, Babak Emamalizadeh, Nasim Sohrabifar, Somayeh Kazeminasab\",\"doi\":\"10.1186/s43042-023-00415-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Inter-individual variations in the clinical manifestations of SARS-CoV-2 infection are among the challenging features of COVID-19. The known role of telomeres in cell proliferation and immune competency highlights their possible function in infectious diseases. Variability in telomere length is an invaluable parameter in the heterogeneity of the clinical presentation of diseases.</p><p><strong>Result: </strong>In this study, our aim was to investigate the possible association between leukocyte telomere length (LTL) and COVID-19 severity. LTL was measured in 100 patients with moderate and severe forms of COVID-19 using the quantitative PCR (q-PCR) method. Statistical analysis confirmed a strong inverse correlation between relative LTL and COVID-19 severity.</p><p><strong>Conclusions: </strong>These findings suggest that LTL can be a useful parameter for predicting disease severity in patients, as individuals with short telomeres may have a higher risk of developing severe COVID-19.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1186/s43042-023-00415-z.</p>\",\"PeriodicalId\":74994,\"journal\":{\"name\":\"The Egyptian journal of medical human genetics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225776/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Egyptian journal of medical human genetics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/s43042-023-00415-z\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/5/29 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Egyptian journal of medical human genetics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s43042-023-00415-z","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/5/29 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Association between leukocyte telomere length and COVID-19 severity.
Background: Inter-individual variations in the clinical manifestations of SARS-CoV-2 infection are among the challenging features of COVID-19. The known role of telomeres in cell proliferation and immune competency highlights their possible function in infectious diseases. Variability in telomere length is an invaluable parameter in the heterogeneity of the clinical presentation of diseases.
Result: In this study, our aim was to investigate the possible association between leukocyte telomere length (LTL) and COVID-19 severity. LTL was measured in 100 patients with moderate and severe forms of COVID-19 using the quantitative PCR (q-PCR) method. Statistical analysis confirmed a strong inverse correlation between relative LTL and COVID-19 severity.
Conclusions: These findings suggest that LTL can be a useful parameter for predicting disease severity in patients, as individuals with short telomeres may have a higher risk of developing severe COVID-19.
Supplementary information: The online version contains supplementary material available at 10.1186/s43042-023-00415-z.
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