自体转运蛋白Vag8免疫可预防小鼠百日咳博德特拉感染引起的咳嗽

IF 1.9 4区医学 Q4 IMMUNOLOGY

Microbiology and Immunology Pub Date : 2023-03-28 DOI:10.1111/1348-0421.13066

Koichiro Suzuki, Yukihiro Hiramatsu, Takashi Nishida, Yasuhiko Horiguchi

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引用次数: 1

摘要

百日咳博德泰拉引起百日咳，其特征是阵发性咳嗽。这种疾病通常通过接种疫苗来预防;然而，尽管疫苗接种覆盖率很高，但全世界百日咳病例的数量仍在增加。我们以前报道过百日咳白杆菌的一种自身转运体，毒力相关基因8 (Vag8)，与百日咳毒素和低脂多糖联合引起咳嗽。在这里，我们发现用Vag8免疫可以保护小鼠免受百日咳感染后的咳嗽，并增强了目前含有百日咳类毒素的百日咳疫苗对咳嗽的功效。我们的研究结果表明，Vag8可能是预防百日咳的疫苗抗原。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Immunization with autotransporter Vag8 prevents coughing induced by Bordetella pertussis infection in mice

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Immunization with autotransporter Vag8 prevents coughing induced by Bordetella pertussis infection in mice

Bordetella pertussis causes pertussis, which is characterized by paroxysmal coughing. This disease is generally prevented through vaccination; however, the number of pertussis cases is increasing worldwide despite high vaccination coverage. We previously reported that an autotransporter of B. pertussis, virulence-associated gene 8 (Vag8), causes coughing in combination with pertussis toxin and lipooligosaccharide. Here, we show that immunization with Vag8 protected mice from coughing after B. pertussis infection and enhanced the efficacy of a current pertussis vaccine containing pertussis toxoid against the cough. Our findings indicate that Vag8 could be a vaccine antigen to prevent pertussis cough.

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来源期刊

Microbiology and Immunology 医学-免疫学

CiteScore

5.20

自引率

3.80%

发文量

审稿时长

1 months

期刊介绍： Microbiology and Immunology is published in association with Japanese Society for Bacteriology, Japanese Society for Virology, and Japanese Society for Host Defense Research. It is peer-reviewed publication that provides insight into the study of microbes and the host immune, biological and physiological responses. Fields covered by Microbiology and Immunology include:Bacteriology|Virology|Immunology|pathogenic infections in human, animals and plants|pathogenicity and virulence factors such as microbial toxins and cell-surface components|factors involved in host defense, inflammation, development of vaccines|antimicrobial agents and drug resistance of microbes|genomics and proteomics.