一种用于创伤急救的有效止血和抗菌的水凝胶急救组织胶粘剂。

IF 11.3 1区 医学 Q1 Medicine
Dongjie Zhang, Li Mei, Yuanping Hao, Bingcheng Yi, Jilin Hu, Danyang Wang, Yaodong Zhao, Zhe Wang, Hailin Huang, Yongzhi Xu, Xuyang Deng, Cong Li, Xuewei Li, Qihui Zhou, Yun Lu
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引用次数: 1

摘要

背景:临床组织粘接剂在处理急诊损伤时仍然存在一些严重的缺陷,如粘接剂强度不足和抗感染能力不足。本文设计了一种新型的、自愈的、抗菌的羧甲基壳聚糖/聚醛葡聚糖(CMCS/PD)水凝胶作为有效的创伤应急处理的急救组织粘接剂。方法:考察其成胶时间、孔隙度、自愈性、抗菌性能、细胞毒性、黏附强度和血液相容性。分别建立大鼠肝出血模型、断尾模型和皮肤创面感染模型。结果:结果表明,CMCS/PD水凝胶具有快速成胶(~ 5 s)、良好的自愈性和有效的抗菌能力,并能牢固地粘附组织(粘附强度~ 10 kPa,破裂压力327.5 mmHg),具有良好的血液相容性和细胞相容性。这表明CMCS/PD水凝胶作为创伤急救组织粘接剂具有广阔的应用前景。与商业止血凝胶(Surgiflo®)相比,CMCS/PD水凝胶不仅可以快速止血治疗肝出血和尾裂,而且与临床消毒凝胶(Prontosan®)相比,在治疗急性皮肤创伤方面也具有优越的抗感染能力。结论:总的来说,CMCS/PD水凝胶是一种很有前途的创伤急救组织粘接剂。由于凝胶形成时间快,它也可以作为液体急救绷带用于微创手术治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A hydrogel-based first-aid tissue adhesive with effective hemostasis and anti-bacteria for trauma emergency management.

Background: Clinical tissue adhesives remain some critical drawbacks for managing emergency injuries, such as inadequate adhesive strength and insufficient anti-infection ability. Herein, a novel, self-healing, and antibacterial carboxymethyl chitosan/polyaldehyde dextran (CMCS/PD) hydrogel is designed as the first-aid tissue adhesive for effective trauma emergency management.

Methods: We examined the gel-forming time, porosity, self-healing, antibacterial properties, cytotoxicity, adhesive strength, and hemocompatibility. Liver hemorrhage, tail severance, and skin wound infection models of rats are constructed in vivo, respectively.

Results: Results demonstrate that the CMCS/PD hydrogel has the rapid gel-forming (~ 5 s), good self-healing, and effective antibacterial abilities, and could adhere to tissue firmly (adhesive strength of ~ 10 kPa and burst pressure of 327.5 mmHg) with excellent hemocompatibility and cytocompatibility. This suggests the great prospect of CMCS/PD hydrogel in acting as a first-aid tissue adhesive for trauma emergency management. The CMCS/PD hydrogel is observed to not only achieve rapid hemostasis for curing liver hemorrhage and tail severance in comparison to commercial hemostatic gel (Surgiflo ®) but also exhibit superior anti-infection for treating acute skin trauma compared with clinical disinfectant gel (Prontosan ®).

Conclusions: Overall, the CMCS/PD hydrogel offers a promising candidate for first-aid tissue adhesives to manage the trauma emergency. Because of the rapid gel-forming time, it could also be applied as a liquid first-aid bandage for mini-invasive surgical treatment.

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来源期刊
Biomaterials Research
Biomaterials Research Medicine-Medicine (miscellaneous)
CiteScore
10.20
自引率
3.50%
发文量
63
审稿时长
30 days
期刊介绍: Biomaterials Research, the official journal of the Korean Society for Biomaterials, is an open-access interdisciplinary publication that focuses on all aspects of biomaterials research. The journal covers a wide range of topics including novel biomaterials, advanced techniques for biomaterial synthesis and fabrication, and their application in biomedical fields. Specific areas of interest include functional biomaterials, drug and gene delivery systems, tissue engineering, nanomedicine, nano/micro-biotechnology, bio-imaging, regenerative medicine, medical devices, 3D printing, and stem cell research. By exploring these research areas, Biomaterials Research aims to provide valuable insights and promote advancements in the biomaterials field.
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