Kehinde S Okunade, Kabir B Badmos, Adaiah P Soibi-Harry, Sunusi-Rimi Garba, Ephraim O Ohazurike, Oluchi Ozonu, Alani S Akanmu, Folasade T Ogunsola, Fatimah B Abdulkareem, Rose I Anorlu
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引用次数: 0
摘要
导言:在大多数资源有限的环境中,为所有感染艾滋病病毒的妇女提供宫颈癌筛查服务可能并不可行,因此有必要确定哪些妇女的风险最高。我们确定了尼日利亚拉各斯受 HIV 感染妇女宫颈细胞学异常的患病率、模式和相关因素:这项描述性横断面研究于 2018 年 10 月至 2019 年 12 月期间在尼日利亚拉各斯一所大学教学医院的成人 HIV 治疗和阴道镜检查诊所的 HIV 感染妇女中进行。研究收集了每位妇女的宫颈样本,以检测宫颈细胞学异常:在登记的 593 名妇女中,有 40 人(6.7%)存在宫颈细胞学异常。大多数(37.5%)细胞学异常的妇女都有意义不明的非典型鳞状细胞。初次月经的年龄(结论:宫颈细胞学异常的发生率较高:在我们的研究中,宫颈细胞学异常的发病率低于非洲以往的大多数报告。初次性行为的年龄过早与细胞学异常有很大关系。有必要通过一项设计合理、充分有效的纵向研究来证实本研究的结果。
Cervical Epithelial Abnormalities and Associated Factors among HIV-Infected Women in Lagos, Nigeria: A Cytology-Based Study.
Introduction: As it may not be feasible to provide cervical cancer screening services to all HIV-infected women in most resource-limited settings, there is a need to identify those who are most at risk. We determined the prevalence, patterns, and associated factors of cervical cytological abnormalities among HIV-infected women in Lagos, Nigeria.
Methods: This descriptive cross-sectional study was conducted among HIV-infected women at the adult HIV treatment and colposcopy clinics of a university teaching hospital in Lagos, Nigeria, between October 2018 and December 2019. A cervical sample was collected from each woman to detect cervical cytological abnormalities.
Results: Of the 593 enrolled women, cervical cytological abnormalities were present in 40 (6.7%). Most (37.5%) of the women with cytological abnormalities had atypical squamous cells of undetermined significance. Age at coitarche (<20 vs. ≥20 years: adjusted odds ratio, 2.42; 95% confidence interval, 1.21-4.83, p = 0.01) was the only factor that was independently associated with cervical epithelial abnormalities.
Conclusion: The prevalence of cervical cytological abnormalities in our study is lower than most previous reports in Africa. Sexual debut at an early age was significantly associated with cytological abnormalities. It is necessary to confirm the findings of this study through a well-designed and adequately powered longitudinal study.
期刊介绍:
With articles offering an excellent balance between clinical cytology and cytopathology, ''Acta Cytologica'' fosters the understanding of the pathogenetic mechanisms behind cytomorphology and thus facilitates the translation of frontline research into clinical practice. As the official journal of the International Academy of Cytology and affiliated to over 50 national cytology societies around the world, ''Acta Cytologica'' evaluates new and existing diagnostic applications of scientific advances as well as their clinical correlations. Original papers, review articles, meta-analyses, novel insights from clinical practice, and letters to the editor cover topics from diagnostic cytopathology, gynecologic and non-gynecologic cytopathology to fine needle aspiration, molecular techniques and their diagnostic applications. As the perfect reference for practical use, ''Acta Cytologica'' addresses a multidisciplinary audience practicing clinical cytopathology, cell biology, oncology, interventional radiology, otorhinolaryngology, gastroenterology, urology, pulmonology and preventive medicine.