染色质和转录调控在真菌有性子实体形成中的作用。

IF 8 1区 生物学 Q1 MICROBIOLOGY
Microbiology and Molecular Biology Reviews Pub Date : 2022-12-21 Epub Date: 2022-11-21 DOI:10.1128/mmbr.00104-22
Minou Nowrousian
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引用次数: 0

摘要

真菌子实体是复杂的三维结构,由较不复杂的营养菌丝体产生。它们的形成需要许多基因及其基因产物的协同作用,子实体的形成伴随着转录组的重大变化。近年来,人们发现了许多参与子实体形态发生的转录因子基因和染色质修饰基因,通过对几种模式生物的研究,染色质结构、基因表达和细胞分化的潜在调控网络越来越清晰。本文综述了转录调控和染色质结构在子实体发育中的作用的研究现状。在第一部分中,描述了转录组学分析的见解,重点是比较转录组学。在第二部分中,我们讨论了染色质修饰剂和/或转录因子在几种模式生物(粗神经孢子菌、细粒曲霉、大孢子索达菌、铜opsis cinerea和Schizophyllum commune)中更详细的功能特征,这些特征有助于更好地理解染色质结构和转录水平上的调控网络。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Role of Chromatin and Transcriptional Control in the Formation of Sexual Fruiting Bodies in Fungi.

Fungal fruiting bodies are complex, three-dimensional structures that arise from a less complex vegetative mycelium. Their formation requires the coordinated action of many genes and their gene products, and fruiting body formation is accompanied by major changes in the transcriptome. In recent years, numerous transcription factor genes as well as chromatin modifier genes that play a role in fruiting body morphogenesis were identified, and through research on several model organisms, the underlying regulatory networks that integrate chromatin structure, gene expression, and cell differentiation are becoming clearer. This review gives a summary of the current state of research on the role of transcriptional control and chromatin structure in fruiting body development. In the first part, insights from transcriptomics analyses are described, with a focus on comparative transcriptomics. In the second part, examples of more detailed functional characterizations of the role of chromatin modifiers and/or transcription factors in several model organisms (Neurospora crassa, Aspergillus nidulans, Sordaria macrospora, Coprinopsis cinerea, and Schizophyllum commune) that have led to a better understanding of regulatory networks at the level of chromatin structure and transcription are discussed.

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来源期刊
CiteScore
18.80
自引率
0.80%
发文量
27
期刊介绍: Microbiology and Molecular Biology Reviews (MMBR), a journal that explores the significance and interrelationships of recent discoveries in various microbiology fields, publishes review articles that help both specialists and nonspecialists understand and apply the latest findings in their own research. MMBR covers a wide range of topics in microbiology, including microbial ecology, evolution, parasitology, biotechnology, and immunology. The journal caters to scientists with diverse interests in all areas of microbial science and encompasses viruses, bacteria, archaea, fungi, unicellular eukaryotes, and microbial parasites. MMBR primarily publishes authoritative and critical reviews that push the boundaries of knowledge, appealing to both specialists and generalists. The journal often includes descriptive figures and tables to enhance understanding. Indexed/Abstracted in various databases such as Agricola, BIOSIS Previews, CAB Abstracts, Cambridge Scientific Abstracts, Chemical Abstracts Service, Current Contents- Life Sciences, EMBASE, Food Science and Technology Abstracts, Illustrata, MEDLINE, Science Citation Index Expanded (Web of Science), Summon, and Scopus, among others.
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