新冠肺炎感染机制和潜在靶点的新认识:三种中成药和三种中药方剂有望成为治疗新冠肺炎的途径

IF 4.7 4区 医学 Q1 CHEMISTRY, MEDICINAL
Kexin Jia , Yijie Li , Tiegang Liu , Xiaohong Gu , Xiaojiaoyang Li
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引用次数: 1

摘要

由高致病性和传染性的严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)引起的2019冠状病毒病(新冠肺炎)已成为全球范围内一种突然致命的流行病。目前,新冠肺炎治疗尚无公认的特效药。因此,明确新冠肺炎患者的发病机制,开发有效的治疗方法迫在眉睫。根据来自中国的几份可靠报告,中药,特别是三种中成药和三种中药配方,已被证明可以有效缓解新冠肺炎的症状,无论是单独使用还是与西药联合使用。在这篇综述中,我们系统地总结和分析了新冠肺炎的发病机制、三种中成药和三种中药配方在新冠肺炎抗击中的详细临床实践、有效成分调查、网络药理学预测和潜在机制验证。此外,我们总结了这些处方中一些有前景的高频药物,并讨论了它们的调节机制,为开发新的抗新冠肺炎药物提供了指导。总之,通过应对这些药物和配方的关键挑战,例如目标不明确和活性成分复杂,我们相信中医药将成为治疗新冠肺炎和相关流行病的有前途和有效的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
New insights for infection mechanism and potential targets of COVID-19: Three Chinese patent medicines and three Chinese medicine formulas as promising therapeutic approaches

The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with high pathogenicity and infectiousness has become a sudden and lethal pandemic worldwide. Currently, there is no accepted specific drug for COVID-19 treatment. Therefore, it is extremely urgent to clarify the pathogenic mechanism and develop effective therapies for patients with COVID-19. According to several reliable reports from China, traditional Chinese medicine (TCM), especially for three Chinese patent medicines and three Chinese medicine formulas, has been demonstrated to effectively alleviate the symptoms of COVID-19 either used alone or in combination with Western medicines. In this review, we systematically summarized and analyzed the pathogenesis of COVID-19, the detailed clinical practice, active ingredients investigation, network pharmacology prediction and underlying mechanism verification of three Chinese patent medicines and three Chinese medicine formulas in the COVID-19 combat. Additionally, we summarized some promising and high-frequency drugs of these prescriptions and discussed their regulatory mechanism, which provides guidance for the development of new drugs against COVID-19. Collectively, by addressing critical challenges, for example, unclear targets and complicated active ingredients of these medicines and formulas, we believe that TCM will represent promising and efficient strategies for curing COVID-19 and related pandemics.

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来源期刊
Chinese Herbal Medicines
Chinese Herbal Medicines CHEMISTRY, MEDICINAL-
CiteScore
4.40
自引率
5.30%
发文量
629
审稿时长
10 weeks
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