Podoplanin在唾液腺癌中的表达及其临床意义。免疫组织化学研究。

IF 0.7 4区 医学 Q4 PATHOLOGY
Samar Soliman, Mahmoud F Elsherbeny, Heba Sheta, Abdelaty Shawky Mohamed, Maha M Fawzy, Doaa H Sakr, Nadia Lotfy
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引用次数: 0

摘要

Podoplanin (D2-40)是一种淋巴内皮标志物,被认为是唾液腺癌(SGCs)中淋巴内皮细胞和淋巴管生成的特异性标志物。目的:探讨足磷脂蛋白在SGCs中的免疫组化表达及其与临床病理参数和患者生存期的关系。电子选择49例SGC病例。对人口学、临床、实验室和生存数据进行回顾并制成表格。免疫组化使用antipodoplanin。根据评分系统将病例分为低表达和高表达。0 ~ 1分为低表达,> 1分为高表达。Podoplanin高表达占46.9%,低表达占53.1%。podoplanin表达与肿瘤分级(p≤0.001)、肿瘤-淋巴结-转移(TNM)分期(p≤0.001)、肿瘤大小(p≤0.001)、淋巴结转移(p≤0.001)、肿瘤类型(p = 0.03)、预后(p≤0.001)、死亡率(p≤0.001)有显著的统计学相关性。高表达和低表达患者的总生存期和无进展生存期差异显著(p≤0.001)。Podoplanin过表达可能是SGCs患者的重要预后指标,这意味着它是提高这些癌症患者生存率的潜在治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Podoplanin expression in salivary gland carcinomas and its clinical significance. An immunohistochemical study.

Podoplanin (D2-40) is a lymphatic endothelial marker that is considered as a specific marker for lymphatic endothelial cells and lymphangiogenesis in salivary gland carcinomas (SGCs). Aim: the present study aimed to investigate the immunohistochemical expression of podoplanin in SGCs and to correlate its expression with the clinicopathological parameters and patients' survival. Forty-nine SGC cases were electronically selected. Demographic, clinical, laboratory, and survival data were reviewed and tabulated. Immunohistochemistry was performed using antipodoplanin. Cases were divided into low and high expression based on a scoring system. A score of 0 and 1 was considered low expression, while > 1 was considered high expression. Podoplanin high expression was seen in 46.9% of cases, and 53.1% of cases showed low expression. Significant statistical associations were seen between podoplanin expression and tumour grade ( p ≤ 0.001), tumour-nodal- metastasis (TNM) stage (p ≤ 0.001), tumour size (p ≤ 0.001), nodal metastasis (p ≤ 0.001), tumour type (p = 0.03), prognosis (p ≤ 0.001), and mortality (p ≤ 0.001). The overall survival and progression-free survival differed significantly in cases with high and low expression (p ≤ 0.001). Podoplanin overexpression might be a significant prognostic indicator for patients with SGCs, implicating that it is a potential therapeutic target to improve survival in these cancer patients.

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来源期刊
CiteScore
1.00
自引率
0.00%
发文量
21
审稿时长
>12 weeks
期刊介绍: Polish Journal of Pathology is an official magazine of the Polish Association of Pathologists and the Polish Branch of the International Academy of Pathology. For the last 18 years of its presence on the market it has published more than 360 original papers and scientific reports, often quoted in reviewed foreign magazines. A new extended Scientific Board of the quarterly magazine comprises people with recognised achievements in pathomorphology and biology, including molecular biology and cytogenetics, as well as clinical oncology. Polish scientists who are working abroad and are international authorities have also been invited. Apart from presenting scientific reports, the magazine will also play a didactic and training role.
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