中国癌症疼痛患者对镇痛药物的依从性及其相关因素的横断面研究

IF 2 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Xincai Zhao, Rong Xu, Yonggang Wang, Yan Zhou, Jin Lu, Wanhu Zhu, Yao Qiu, Quanjun Yang, Zan Shen, Cheng Guo, Jianping Zhang
{"title":"中国癌症疼痛患者对镇痛药物的依从性及其相关因素的横断面研究","authors":"Xincai Zhao,&nbsp;Rong Xu,&nbsp;Yonggang Wang,&nbsp;Yan Zhou,&nbsp;Jin Lu,&nbsp;Wanhu Zhu,&nbsp;Yao Qiu,&nbsp;Quanjun Yang,&nbsp;Zan Shen,&nbsp;Cheng Guo,&nbsp;Jianping Zhang","doi":"10.5993/AJHB.47.1.4","DOIUrl":null,"url":null,"abstract":"<p><p><b>Objectives:</b> Pain is one of the most common and distressing symptoms co-occurring with cancer progression and treatment, and medication adherence plays an important role in achieving good pain control. However, research on medication adherence and influential factors among individuals with cancer pain (CP) is limited in China. The present study aimed to investigate the adherence to analgesics in patients with CP in China and to identify factors that may influence adherence. <b>Methods:</b> A cross-sectional study was conducted from June 2020 to February 2021. Study instruments consisted of a set of validated questionnaires, 5 measurement instruments including the numerical rating scale (NRS), ID-Pain, Morisky Medication Adherence Scale-Chinese validated version (MMAS-C), Beliefs about Medicines Questionnaire (BMQ) - Specific, and the Hospital Anxiety and Depression Scale (HADS). <b>Results:</b> A total of 141 participants with CP including 71 males (50.4%), aged 54.5±15.5 years were surveyed in this study. Overall, 83 patients (58.9%) showed adherence, but 58 patients (41.1%) showed non-adherence to analgesics. The univariate analysis showed that analgesic adherence was associated with pain duration of>3 months, outbreaks of pain in the last 24 hours, presence of side effects, getting analgesics in time, presence of neuropathic pain, stopping analgesics or adjusting dosage by themselves, presence of anxiety and depression, and beliefs about medicines. Moreover, the multivariate logistic regression showed that getting analgesic drugs in time (odds ratio [OR]=5.218, 95% confidence interval [CI] 1.691-16.100) and high BMQ-Necessity (OR=1.907, 95% CI 1.418-2.565) were associated with high adherence, stopping analgesics or adjusting dosage by themselves (OR=7.958, 95% CI 2.443-25.926) and high BMQ-Concern (OR=0.760, 95% CI 0.600-0.964) were more likely to be associated with non-adherence. <b>Conclusion:</b> In view of our findings, it may be critical for individuals to have a better understanding and strong beliefs about their prescribed analgesic drugs. Pain education, counseling and follow-up of patients and their caregivers, and removal of barriers to accessing analgesic drugs could be considered in further intervention strategies.</p>","PeriodicalId":7699,"journal":{"name":"American journal of health behavior","volume":"47 1","pages":"30-39"},"PeriodicalIF":2.0000,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Adherence to Analgesic Drugs and its Associated Factors among Patients with Cancer Pain: A Crosssectional Study in China.\",\"authors\":\"Xincai Zhao,&nbsp;Rong Xu,&nbsp;Yonggang Wang,&nbsp;Yan Zhou,&nbsp;Jin Lu,&nbsp;Wanhu Zhu,&nbsp;Yao Qiu,&nbsp;Quanjun Yang,&nbsp;Zan Shen,&nbsp;Cheng Guo,&nbsp;Jianping Zhang\",\"doi\":\"10.5993/AJHB.47.1.4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Objectives:</b> Pain is one of the most common and distressing symptoms co-occurring with cancer progression and treatment, and medication adherence plays an important role in achieving good pain control. However, research on medication adherence and influential factors among individuals with cancer pain (CP) is limited in China. The present study aimed to investigate the adherence to analgesics in patients with CP in China and to identify factors that may influence adherence. <b>Methods:</b> A cross-sectional study was conducted from June 2020 to February 2021. Study instruments consisted of a set of validated questionnaires, 5 measurement instruments including the numerical rating scale (NRS), ID-Pain, Morisky Medication Adherence Scale-Chinese validated version (MMAS-C), Beliefs about Medicines Questionnaire (BMQ) - Specific, and the Hospital Anxiety and Depression Scale (HADS). <b>Results:</b> A total of 141 participants with CP including 71 males (50.4%), aged 54.5±15.5 years were surveyed in this study. Overall, 83 patients (58.9%) showed adherence, but 58 patients (41.1%) showed non-adherence to analgesics. The univariate analysis showed that analgesic adherence was associated with pain duration of>3 months, outbreaks of pain in the last 24 hours, presence of side effects, getting analgesics in time, presence of neuropathic pain, stopping analgesics or adjusting dosage by themselves, presence of anxiety and depression, and beliefs about medicines. Moreover, the multivariate logistic regression showed that getting analgesic drugs in time (odds ratio [OR]=5.218, 95% confidence interval [CI] 1.691-16.100) and high BMQ-Necessity (OR=1.907, 95% CI 1.418-2.565) were associated with high adherence, stopping analgesics or adjusting dosage by themselves (OR=7.958, 95% CI 2.443-25.926) and high BMQ-Concern (OR=0.760, 95% CI 0.600-0.964) were more likely to be associated with non-adherence. <b>Conclusion:</b> In view of our findings, it may be critical for individuals to have a better understanding and strong beliefs about their prescribed analgesic drugs. Pain education, counseling and follow-up of patients and their caregivers, and removal of barriers to accessing analgesic drugs could be considered in further intervention strategies.</p>\",\"PeriodicalId\":7699,\"journal\":{\"name\":\"American journal of health behavior\",\"volume\":\"47 1\",\"pages\":\"30-39\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2023-02-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American journal of health behavior\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5993/AJHB.47.1.4\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of health behavior","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5993/AJHB.47.1.4","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
引用次数: 0

摘要

目的:疼痛是与癌症进展和治疗同时发生的最常见和令人痛苦的症状之一,药物依从性对实现良好的疼痛控制起着重要作用。然而,国内对癌性疼痛患者的药物依从性及其影响因素的研究较少。本研究旨在调查中国CP患者对镇痛药的依从性,并确定可能影响依从性的因素。方法:于2020年6月至2021年2月进行横断面研究。研究工具包括一套有效问卷,5种测量工具,包括数字评定量表(NRS)、ID-Pain、Morisky药物依从性量表-中文版(MMAS-C)、药物信念问卷(BMQ) -特异性和医院焦虑抑郁量表(HADS)。结果:共调查了141例CP患者,其中男性71例(50.4%),年龄54.5±15.5岁。总体而言,83例患者(58.9%)表现出镇痛药物的依从性,58例患者(41.1%)表现出镇痛药物的不依从性。单因素分析显示,镇痛依从性与疼痛持续时间>3个月、最近24小时内疼痛发作、是否出现副作用、是否及时获得镇痛药、是否出现神经性疼痛、自行停药或调整剂量、是否出现焦虑和抑郁以及对药物的信念有关。多因素logistic回归分析显示,及时获得镇痛药物(比值比[OR]=5.218, 95%可信区间[CI] 1.691 ~ 16.100)和高BMQ-Necessity (OR=1.907, 95% CI 1.418 ~ 2.565)与高依从性相关,自行停用镇痛或调整剂量(OR=7.958, 95% CI 2.44 ~ 25.926)和高BMQ-Concern (OR=0.760, 95% CI 0.600 ~ 0.964)与不依从性相关。结论:鉴于我们的研究结果,个体对其处方镇痛药物有更好的理解和坚定的信念可能是至关重要的。在进一步的干预策略中,可以考虑对患者及其护理人员进行疼痛教育、咨询和随访,以及消除获得镇痛药物的障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Adherence to Analgesic Drugs and its Associated Factors among Patients with Cancer Pain: A Crosssectional Study in China.

Objectives: Pain is one of the most common and distressing symptoms co-occurring with cancer progression and treatment, and medication adherence plays an important role in achieving good pain control. However, research on medication adherence and influential factors among individuals with cancer pain (CP) is limited in China. The present study aimed to investigate the adherence to analgesics in patients with CP in China and to identify factors that may influence adherence. Methods: A cross-sectional study was conducted from June 2020 to February 2021. Study instruments consisted of a set of validated questionnaires, 5 measurement instruments including the numerical rating scale (NRS), ID-Pain, Morisky Medication Adherence Scale-Chinese validated version (MMAS-C), Beliefs about Medicines Questionnaire (BMQ) - Specific, and the Hospital Anxiety and Depression Scale (HADS). Results: A total of 141 participants with CP including 71 males (50.4%), aged 54.5±15.5 years were surveyed in this study. Overall, 83 patients (58.9%) showed adherence, but 58 patients (41.1%) showed non-adherence to analgesics. The univariate analysis showed that analgesic adherence was associated with pain duration of>3 months, outbreaks of pain in the last 24 hours, presence of side effects, getting analgesics in time, presence of neuropathic pain, stopping analgesics or adjusting dosage by themselves, presence of anxiety and depression, and beliefs about medicines. Moreover, the multivariate logistic regression showed that getting analgesic drugs in time (odds ratio [OR]=5.218, 95% confidence interval [CI] 1.691-16.100) and high BMQ-Necessity (OR=1.907, 95% CI 1.418-2.565) were associated with high adherence, stopping analgesics or adjusting dosage by themselves (OR=7.958, 95% CI 2.443-25.926) and high BMQ-Concern (OR=0.760, 95% CI 0.600-0.964) were more likely to be associated with non-adherence. Conclusion: In view of our findings, it may be critical for individuals to have a better understanding and strong beliefs about their prescribed analgesic drugs. Pain education, counseling and follow-up of patients and their caregivers, and removal of barriers to accessing analgesic drugs could be considered in further intervention strategies.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
American journal of health behavior
American journal of health behavior PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
3.30
自引率
0.00%
发文量
82
期刊介绍: The Journal seeks to improve the quality of life through multidisciplinary health efforts in fostering a better understanding of the multidimensional nature of both individuals and social systems as they relate to health behaviors.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信