新型4-氯- n -苯基苯酰胺衍生物作为p38α有丝分裂原激活蛋白激酶抑制剂治疗癌症、COVID-19和其他疾病

IF 2.5 4区医学 Q3 ONCOLOGY

Recent patents on anti-cancer drug discovery Pub Date : 2023-01-01 DOI:10.2174/1574892818666221202111605

Surya K De

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引用次数: 0

摘要

本公开涉及p38α丝裂原激活的蛋白激酶抑制剂及其药物组合物，以及p38α丝裂原激活的蛋白激酶抑制剂及其药物组合物用于治疗各种疾病，如癌症、类风湿关节炎、肌萎缩性侧索硬化、囊性纤维化、心血管疾病、多发性硬化症、炎症性肠病、慢性阻塞性肺疾病(COPD)、哮喘、COVID-19、急性呼吸窘迫综合征(ARDS)和急性肺损伤(ALI)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Novel 4-chloro-N-phenyl Benzamide Derivatives as p38α Mitogenactivated Protein Kinase Inhibitors for Treating Cancer, COVID-19, and Other Diseases.

The present disclosure relates to p38α mitogen-activated protein kinase inhibitors, pharmaceutical compositions thereof, and the use of the p38α mitogen-activated protein kinase inhibitors and pharmaceutical compositions thereof for treating various diseases such as cancer, rheumatoid arthritis, amyotrophic lateral sclerosis, cystic fibrosis, cardiovascular disease, multiple sclerosis, inflammatory bowel disease, chronic obstructive pulmonary disease (COPD), asthma, COVID-19, acute respiratory distress syndrome (ARDS), and acute lung injury (ALI).

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来源期刊

Recent patents on anti-cancer drug discovery 医学-药学

CiteScore

4.50

自引率

7.10%

发文量

审稿时长

3 months

期刊介绍： Aims & Scope Recent Patents on Anti-Cancer Drug Discovery publishes review and research articles that reflect or deal with studies in relation to a patent, application of reported patents in a study, discussion of comparison of results regarding application of a given patent, etc., and also guest edited thematic issues on recent patents in the field of anti-cancer drug discovery e.g. on novel bioactive compounds, analogs, targets & predictive biomarkers & drug efficacy biomarkers. The journal also publishes book reviews of eBooks and books on anti-cancer drug discovery. A selection of important and recent patents on anti-cancer drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-cancer drug design and discovery. The journal also covers recent research (where patents have been registered) in fast emerging therapeutic areas/targets & therapeutic agents related to anti-cancer drug discovery.