2016 - 2021年长沙市淋病奈瑟菌分离株药敏及分子特征监测

IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES
Qianqin Yuan, Shiya Shi, Yufeng Dai, Mengjie Jiang, Ping Jiang, Danning Xu, Qinglin Liu, Chuanhao Jiang, Xinwu Guo, Hongzhi Chen, Lingli Tang
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引用次数: 1

摘要

抗生素治疗对感染淋病的个体和预防疾病传播至关重要。本研究旨在分析长沙地区淋病奈瑟菌分离株的抗菌药物敏感性和分子流行病学特征。采用琼脂稀释法对2016 - 2021年两所医院临床实验室采集的271株淋病奈瑟菌进行药敏分析。采用淋病奈瑟菌多抗原序列分型(NG-MAST)进行基因分型,并用porB和tbpB序列进行系统发育分析。结果显示,对环丙沙星、四环素和青霉素的耐药性较高,这些药物已不再推荐用于治疗淋病。所有分离株均对大观霉素敏感。然而,2016-2021年共发现头孢曲松(CRO)耐药菌株15株(5.5%),CRO敏感性降低的菌株31株(11.4%),2016-2017年对阿奇霉素的耐药率为7.1%。流行病学上,在所有抗cro菌株中均鉴定出花叶型penA等位基因。NG-MAST检测结果显示ST5061是最常见的ST.菌株,系统发育分析表明耐药菌株不是独立聚集的。尽管本研究着眼于当地情况,但提出了改善淋病药物治疗的必要性,并强调CRO可能不足以作为长沙市淋病的一线治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Surveillance of the Antimicrobial Susceptibility and Molecular Characteristics of Neisseria gonorrhoeae Isolates Collected in Changsha, China from 2016 to 2021.

Antibiotic treatment is critical for individuals infected with gonorrhea and preventing disease transmission. This study aimed to analyze the antimicrobial susceptibility and molecular epidemiological characteristics of Neisseria gonorrhoeae isolates in Changsha, China. A total of 271 N.gonorrhoeae isolates collected from the clinical laboratories of two hospitals between 2016 and 2021 were analyzed for antimicrobial susceptibility using the agar dilution method. N. gonorrhoeae multi-antigen sequence typing (NG-MAST) was conducted for genotyping, and phylogenetic analysis was performed using the porB and tbpB sequences. The results showed that antimicrobial resistance against ciprofloxacin, tetracycline, and penicillin was high, and these drugs are no longer recommended for the treatment of gonorrhea. All isolates were susceptible to spectinomycin. However, in 2016-2021, a total of 15 (5.5%) ceftriaxone (CRO)-resistant strains and 31 (11.4%) isolates with decreased susceptibility to CRO were found, and the resistance rate to azithromycin had reached 7.1% in 2016-2017. Epidemiologically, the mosaic penA allele was identified in all CRO-resistant isolates. Based on NG-MAST, ST5061 was the most prevalent ST. Phylogenetic analysis suggested that the resistant isolates did not cluster independently. Despite focus on the local situation, this study raises the need for better gonorrhea medication and highlights that CRO may not be adequate as first-line treatment for gonorrhea in Changsha.

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来源期刊
CiteScore
4.50
自引率
4.50%
发文量
172
审稿时长
2 months
期刊介绍: Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.
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