利用实体瘤癌症干细胞模型推进诊断和治疗生物标记的开发。

IF 2 4区医学 Q3 ONCOLOGY

Tumori Pub Date : 2024-02-01 Epub Date: 2023-03-24 DOI:10.1177/03008916231158411

Samuel Sherng Young Wang

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引用次数: 0

摘要

癌症干细胞模型希望解释实体瘤癌变、肿瘤进展和癌症治疗失败的原因。然而，癌症干细胞模型在实体瘤的癌症干细胞生物标志物和靶向治疗方面的临床转化却微乎其微。造成这些挑战的原因有很多，其中之一是对癌症干细胞模型的理解不完善。这篇综述希望通过首先定义癌症干细胞及其相关模型，促进进一步研究可临床转化的癌症干细胞生物标志物。对这些模型有了更好的了解，就能开发出更准确的生物标志物。使生物标志物临床转化为诊断工具和治疗药物更加可行。

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Advancing biomarker development for diagnostics and therapeutics using solid tumour cancer stem cell models.

The cancer stem cell model hopes to explain solid tumour carcinogenesis, tumour progression and treatment failure in cancers. However, the cancer stem cell model has led to minimal clinical translation to cancer stem cell biomarkers and targeted therapies in solid tumours. Many reasons underlie the challenges, one being the imperfect understanding of the cancer stem cell model. This review hopes to spur further research into clinically translatable cancer stem cell biomarkers through first defining cancer stem cells and their associated models. With a better understanding of these models there would be a development of more accurate biomarkers. Making the clinical translation of biomarkers into diagnostic tools and therapeutic agents more feasible.

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来源期刊

Tumori 医学-肿瘤学

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Tumori Journal covers all aspects of cancer science and clinical practice with a strong focus on prevention, translational medicine and clinically relevant reports. We invite the publication of randomized trials and reports on large, consecutive patient series that investigate the real impact of new techniques, drugs and devices inday-to-day clinical practice.