作为诊断和治疗儿科疾病的新型生物标记物的微RNA。

IF 3.2 Q1 PEDIATRICS
Clinical and Experimental Pediatrics Pub Date : 2024-03-01 Epub Date: 2023-05-24 DOI:10.3345/cep.2023.00171
Hwal Rim Jeong, Il Tae Hwang
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引用次数: 0

摘要

微小 RNA(miRNA)是高度保守的非编码 RNA,通过沉默或降解信使 RNA 来调节基因表达。在人类发现的约 2,500 种 miRNA 中,许多都能调节重要的生物过程,包括细胞分化、增殖、凋亡和胚胎组织发育。miRNA 表达异常可能会导致病理和恶性后果。因此,miRNA 已成为各种疾病的新型诊断标志物和潜在治疗靶点。从出生到成年,儿童经历了不同的生长、发育和成熟阶段。研究 miRNA 表达在这些发育阶段的正常生长和疾病发展中的作用非常重要。在这篇微型综述中,我们将讨论 miRNA 作为诊断和预后生物标志物在各种儿科疾病中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
MicroRNAs as novel biomarkers for the diagnosis and treatment of pediatric diseases.

MicroRNAs (miRNAs) are highly conserved noncoding RNAs that regulate gene expression by silencing or degrading messenger RNAs. Many of the approximately 2,500 miRNAs discovered in humans are known to regulate vital biological processes, including cell differentiation, proliferation, apoptosis, and embryonic tissue development. Aberrant miRNA expression may have pathological and malignant consequences. Therefore, miRNAs have emerged as novel diagnostic markers and potential therapeutic targets for various diseases. Children undergo various stages of growth, development, and maturation between birth and adulthood. It is important to study the role of miRNA expression in normal growth and disease development during these developmental stages. In this mini-review, we discuss the role of miRNAs as diagnostic and prognostic biomarkers in various pediatric diseases.

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来源期刊
CiteScore
8.00
自引率
2.40%
发文量
88
审稿时长
60 weeks
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