Alkali-labile神经节甘脂。

IF 2.7 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Glycoconjugate Journal Pub Date : 2023-06-01 DOI:10.1007/s10719-023-10103-0

Laura Mauri, Sandro Sonnino

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引用次数: 0

摘要

讨论了一类经温和碱处理的神经节苷类化合物的结构和性质。我们将介绍携带位置9 o乙酰化的n -乙酰神经氨酸的神经节苷脂的发生和结构，Neu5,9Ac2，以及携带形成内酯环的唾液酸的神经节苷脂。从生化数据出发，我们将讨论这些神经节苷脂在细胞信号传导和脑功能维持过程中可能发挥的生化作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Alkali-labile gangliosides.

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Alkali-labile gangliosides.

The structure and properties of a group of gangliosides modified by mild alkaline treatment are discussed. We will present the occurrence and the structure of gangliosides carrying the N-acetyneuraminic acid O-acetylated in position 9, the Neu5,9Ac₂, and of gangliosides carrying a sialic acid that forms a lactone ring. Starting from biochemical data we will discuss the possible biochemical role played by these gangliosides in the processes of cell signaling and maintenance of brain functions.

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来源期刊

Glycoconjugate Journal 生物-生化与分子生物学

CiteScore

6.00

自引率

3.30%

发文量

审稿时长

1 months

期刊介绍： Glycoconjugate Journal publishes articles and reviews on all areas concerned with: function, composition, structure, biosynthesis, degradation, interactions, recognition and chemo-enzymatic synthesis of glycoconjugates (glycoproteins, glycolipids, oligosaccharides, polysaccharides and proteoglycans), biochemistry, molecular biology, biotechnology, immunology and cell biology of glycoconjugates, aspects related to disease processes (immunological, inflammatory, arthritic infections, metabolic disorders, malignancy, neurological disorders), structural and functional glycomics, glycoimmunology, glycovaccines, organic synthesis of glycoconjugates and the development of methodologies if biologically relevant, glycosylation changes in disease if focused on either the discovery of a novel disease marker or the improved understanding of some basic pathological mechanism, articles on the effects of toxicological agents (alcohol, tobacco, narcotics, environmental agents) on glycosylation, and the use of glycotherapeutics. Glycoconjugate Journal is the official journal of the International Glycoconjugate Organization, which is responsible for organizing the biennial International Symposia on Glycoconjugates.