肌肉骨骼生物学研讨会后基因组分析会议录。

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Cheryl Ackert-Bicknell, David Karasik
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引用次数: 1

摘要

综述的目的:在此,我们报告了题为“肌肉骨骼生物学的后基因组分析”的研讨会的会议记录,该研讨会于2022年7月在以色列加利利的Safed举行。在以色列科学基金会的支持下,这次研讨会的目标是将来自以色列和世界各地对了解肌肉骨骼疾病病因感兴趣的知名研究人员和他们的学员聚集在一起。最近的发现:本次研讨会的报告涵盖了从基础科学到临床研究的各个领域。讨论的重点集中在人类的遗传研究,以及这种研究的局限性和优势。将人类数据与临床前模型(如小鼠、大鼠和斑马鱼)的功能随访研究结合起来进行研究的能力进行了深入讨论。小鼠和斑马鱼忠实地模拟人类疾病方面的优点和局限性进行了辩论,特别是在与年龄相关的疾病,如骨质疏松症、骨关节炎、成人发病的自身免疫性疾病和骨骼肌减少症的背景下。在我们对人类肌肉骨骼疾病的性质和病因的理解上仍有很大的差距。虽然已有治疗和药物,但仍需开展大量工作,为所有患有与年龄相关的肌肉骨骼组织退化相关疾病的患者找到安全有效的干预措施。对于肌肉、关节和骨骼疾病,正向和反向基因研究的潜力尚未耗尽。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Proceedings of the Post-Genome Analysis for Musculoskeletal Biology Workshop.

Purpose of the review: Herein, we report on the proceedings of the workshop entitled "Post-Genome analysis for musculoskeletal biology" that was held in July of 2022 in Safed, Galilee, Israel. Supported by the Israel Science Foundation, the goal of this workshop was to bring together established investigators and their trainees who were interested in understanding the etiology of musculoskeletal disease, from Israel and from around the world.

Recent findings: Presentations at this workshop spanned the spectrum from basic science to clinical studies. A major emphasis of the discussion centered on genetic studies in humans, and the limitations and advantages of such studies. The power of coupling studies using human data with functional follow-up studies in pre-clinical models such as mice, rats, and zebrafish was discussed in depth. The advantages and limitations of mice and zebrafish for faithfully modelling aspects of human disease were debated, specifically in the context of age-related diseases such as osteoporosis, osteoarthritis, adult-onset auto-immune disease, and osteosarcopenia. There remain significant gaps in our understanding of the nature and etiology of human musculoskeletal disease. While therapies and medications exist, much work is still needed to find safe and effective interventions for all patients suffering from diseases associated with age-related deterioration of musculoskeletal tissues. The potential of forward and reverse genetic studies has not been exhausted for diseases of muscles, joints, and bones.

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来源期刊
Current Osteoporosis Reports
Current Osteoporosis Reports Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
8.80
自引率
2.30%
发文量
44
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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