HX和我:理解变构、折叠和蛋白质机器。

IF 10.4 1区生物学 Q1 BIOPHYSICS

Annual Review of Biophysics Pub Date : 2023-05-09 DOI:10.1146/annurev-biophys-062122-093517

S Walter Englander

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引用次数: 1

摘要

我在一开始偶然接触到蛋白质氢交换(HX)，并在我的科学生涯中不断发展，这使我们在HX的测量、解释和前沿生物物理应用方面取得了一系列进展。在思考了生活是如何把我带到了这里之后，我借此机会回顾了我们早期对血红蛋白变构结构和能量变化的研究，以及目前仍在研究的蛋白质折叠问题，以及我们最近对蛋白质机器的前瞻性研究。

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HX and Me: Understanding Allostery, Folding, and Protein Machines.

My accidental encounter with protein hydrogen exchange (HX) at its very beginning and its continued development through my scientific career have led us to a series of advances in HX measurement, interpretation, and cutting edge biophysical applications. After some thoughts about how life brought me there, I take the opportunity to reflect on our early studies of allosteric structure and energy change in hemoglobin, the still-current protein folding problem, and our most recent forward-looking studies on protein machines.

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来源期刊

Annual Review of Biophysics 生物-生物物理

CiteScore

21.00

自引率

0.00%

发文量

期刊介绍： The Annual Review of Biophysics, in publication since 1972, covers significant developments in the field of biophysics, including macromolecular structure, function and dynamics, theoretical and computational biophysics, molecular biophysics of the cell, physical systems biology, membrane biophysics, biotechnology, nanotechnology, and emerging techniques.