{"title":"有氧训练加柚皮苷通过H2S信号通路改善阿尔茨海默病模型大鼠的空间认知","authors":"Mojtaba Salehpour, Ghorbangol Ashabi, Majid Kashef, Elahe Sadat Marashi, Tayyebeh Ghasemi","doi":"10.1080/0361073X.2022.2101303","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This study examined the effects of one-month naringin administration and exercise training on cognitive impairment and H<sub>2</sub>S signaling pathway in an Amyloid β (Aβ)-injected rat.</p><p><strong>Methods: </strong>Rats were divided into four groups: control group; rats underwent Aβ microinjection surgery, exercise group; rats underwent Aβ microinjection surgery and trained by treadmill for four weeks, naringin group; rats underwent Aβ microinjection surgery, and rats orally administrated 80 mg.kg<sup>-1</sup> naringin for four weeks, naringin+exercise group; rats underwent Aβ microinjection surgery and were trained by treadmill for four weeks, and also, rats orally administrated 80 mg.kg<sup>-1</sup> naringin for four weeks. After one month of treatment, spatial learning and memory were measured, and then hippocampi were sampled. S-adenosylmethionine (SAM), cystathionine-β-synthase (CBS), hydrogen sulfide (H<sub>2</sub>S) levels, and neuronal death were detected in the hippocampi of rats.</p><p><strong>Results: </strong>Naringin and exercise improved spatial learning (latency time, P < .001) and memory (P < .001) in the Morris Water Maze test in Aβ-injected rats compared with the control group. SAM (P < .01), CBS (P < .001), and H<sub>2</sub>S (P < .01) levels are increased in the naringin+exercise group compared with the control group.</p><p><strong>Conclusion: </strong>The result of this study supports the effect of exercise and/or naringin to improve cognitive dysfunction and cell death through the production of H<sub>2</sub>S.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Aerobic Training with Naringin Supplementation Improved Spatial Cognition via H<sub>2</sub>S Signaling Pathway in Alzheimer's Disease Model Rats.\",\"authors\":\"Mojtaba Salehpour, Ghorbangol Ashabi, Majid Kashef, Elahe Sadat Marashi, Tayyebeh Ghasemi\",\"doi\":\"10.1080/0361073X.2022.2101303\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>This study examined the effects of one-month naringin administration and exercise training on cognitive impairment and H<sub>2</sub>S signaling pathway in an Amyloid β (Aβ)-injected rat.</p><p><strong>Methods: </strong>Rats were divided into four groups: control group; rats underwent Aβ microinjection surgery, exercise group; rats underwent Aβ microinjection surgery and trained by treadmill for four weeks, naringin group; rats underwent Aβ microinjection surgery, and rats orally administrated 80 mg.kg<sup>-1</sup> naringin for four weeks, naringin+exercise group; rats underwent Aβ microinjection surgery and were trained by treadmill for four weeks, and also, rats orally administrated 80 mg.kg<sup>-1</sup> naringin for four weeks. After one month of treatment, spatial learning and memory were measured, and then hippocampi were sampled. S-adenosylmethionine (SAM), cystathionine-β-synthase (CBS), hydrogen sulfide (H<sub>2</sub>S) levels, and neuronal death were detected in the hippocampi of rats.</p><p><strong>Results: </strong>Naringin and exercise improved spatial learning (latency time, P < .001) and memory (P < .001) in the Morris Water Maze test in Aβ-injected rats compared with the control group. SAM (P < .01), CBS (P < .001), and H<sub>2</sub>S (P < .01) levels are increased in the naringin+exercise group compared with the control group.</p><p><strong>Conclusion: </strong>The result of this study supports the effect of exercise and/or naringin to improve cognitive dysfunction and cell death through the production of H<sub>2</sub>S.</p>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2023-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/0361073X.2022.2101303\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/0361073X.2022.2101303","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Aerobic Training with Naringin Supplementation Improved Spatial Cognition via H2S Signaling Pathway in Alzheimer's Disease Model Rats.
Objectives: This study examined the effects of one-month naringin administration and exercise training on cognitive impairment and H2S signaling pathway in an Amyloid β (Aβ)-injected rat.
Methods: Rats were divided into four groups: control group; rats underwent Aβ microinjection surgery, exercise group; rats underwent Aβ microinjection surgery and trained by treadmill for four weeks, naringin group; rats underwent Aβ microinjection surgery, and rats orally administrated 80 mg.kg-1 naringin for four weeks, naringin+exercise group; rats underwent Aβ microinjection surgery and were trained by treadmill for four weeks, and also, rats orally administrated 80 mg.kg-1 naringin for four weeks. After one month of treatment, spatial learning and memory were measured, and then hippocampi were sampled. S-adenosylmethionine (SAM), cystathionine-β-synthase (CBS), hydrogen sulfide (H2S) levels, and neuronal death were detected in the hippocampi of rats.
Results: Naringin and exercise improved spatial learning (latency time, P < .001) and memory (P < .001) in the Morris Water Maze test in Aβ-injected rats compared with the control group. SAM (P < .01), CBS (P < .001), and H2S (P < .01) levels are increased in the naringin+exercise group compared with the control group.
Conclusion: The result of this study supports the effect of exercise and/or naringin to improve cognitive dysfunction and cell death through the production of H2S.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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