从克隆造血到骨髓增生异常肿瘤/综合征和其他髓系肿瘤的频谱。

IF 2.6 4区医学 Q3 ONCOLOGY

Cancer journal Pub Date : 2023-05-01 DOI:10.1097/PPO.0000000000000656

Zhuoer Xie, Evan C Chen, Lourdes M Mendez, Rami Komrokji, Amer M Zeidan

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引用次数: 0

摘要

摘要:克隆造血(CH)是衰老相关疾病和血液恶性肿瘤的高风险因素。在识别高危CH患者和管理此类患者方面仍存在显著的知识空白。本文主要从3个方面进行综述:(1)植物的自然历史;(2) CH进展的风险，包括潜力不确定的CH、意义不确定的克隆性细胞减少症和治疗相关的CH向髓系恶性肿瘤发展的风险;(3)卫生管理和研究面临的挑战和未满足的需求。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Spectrum From Clonal Hematopoiesis to Myelodysplastic Neoplasm/Syndromes and Other Myeloid Neoplasms.

Abstract: Clonal hematopoiesis (CH) confers a high risk of aging-related diseases and hematologic malignancy. There are still significant knowledge gaps in identifying high-risk patients with CH and managing such patients. In this review, we focus on 3 areas: (1) the natural history of CH; (2) the risks of progression of CH, including CH of indeterminate potential, clonal cytopenia of undetermined significance, and therapy-related CH, to myeloid malignancy; and (3) the challenges and unmet needs of CH management and research.

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来源期刊

Cancer journal 医学-肿瘤学

CiteScore

3.90

自引率

0.00%

发文量

102

审稿时长

7.5 months

期刊介绍： The Cancer Journal: The Journal of Principles & Practice of Oncology provides an integrated view of modern oncology across all disciplines. The Journal publishes original research and reviews, and keeps readers current on content published in the book Cancer: Principles & Practice of Oncology.