FBXO5在癌症中的作用探讨

IF 2.3 3区 生物学 Q3 BIOCHEMICAL RESEARCH METHODS
Junchang Zhang , Gengyuan Zhang , Keshen Wang , Feng Cui, Hanteng Yang, Zuoyi Jiao
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引用次数: 1

摘要

癌症是世界上最常见的恶性肿瘤之一,特别是在中国。由于早期胃癌癌症筛查无效,晚期耐药,癌症的预后仍然惨淡。基于生物信息学和组织微阵列分析,本研究选择FBXO5进行分析。在此,我们报道了FBXO5在癌症中的作用,首次表明它有助于肿瘤细胞增殖、克隆形成、侵袭和迁移。在这些初步发现中,FBXO5促进了细胞周期从G0/G1期向G2/M期的转变,这可能是FBXO5与CDK1和NCAPG蛋白相互作用的结果。需要探讨相关机制。此外,FBXO5参与肿瘤微环境,与免疫激活呈负相关。FBXO5是一种癌基因,在肿瘤的发生和发展中发挥作用,有望成为癌症治疗的潜在靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring the role of FBXO5 in gastric cancer

Gastric cancer is one of the most common lethal malignancies in the world, especially in China. Due to the ineffective screening of early gastric cancer and drug resistance of the advanced, the prognosis of gastric cancer remains dismal. Based on bioinformatics and tissue microarray analyses, FBXO5 was selected for analysis in this study. Here, we report the function of FBXO5 in gastric cancer, showing for the first time that it contributes to tumor cell proliferation, clone formation, invasion and migration. In these preliminary findings, FBXO5 promoted the transition of the cell cycle from the G0/G1 to the G2/M phase, which likely resulted from FBXO5 interacting with CDK1 and NCAPG proteins. The relevant mechanism needs to be explored. In addition, FBXO5 participated in the tumor microenvironment and was negatively related to immune activation. FBXO5, an oncogene, plays a role in tumor initiation and progression, and is expected to be a potential target for gastric cancer treatment.

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来源期刊
Molecular and Cellular Probes
Molecular and Cellular Probes 生物-生化研究方法
CiteScore
6.80
自引率
0.00%
发文量
52
审稿时长
16 days
期刊介绍: MCP - Advancing biology through–omics and bioinformatic technologies wants to capture outcomes from the current revolution in molecular technologies and sciences. The journal has broadened its scope and embraces any high quality research papers, reviews and opinions in areas including, but not limited to, molecular biology, cell biology, biochemistry, immunology, physiology, epidemiology, ecology, virology, microbiology, parasitology, genetics, evolutionary biology, genomics (including metagenomics), bioinformatics, proteomics, metabolomics, glycomics, and lipidomics. Submissions with a technology-driven focus on understanding normal biological or disease processes as well as conceptual advances and paradigm shifts are particularly encouraged. The Editors welcome fundamental or applied research areas; pre-submission enquiries about advanced draft manuscripts are welcomed. Top quality research and manuscripts will be fast-tracked.
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