皮肤源性前体雪旺细胞移植改善双侧海绵状神经损伤模型大鼠勃起功能。

IF 2.4 3区医学 Q2 ANDROLOGY

Basic and Clinical Andrology Pub Date : 2023-05-18 DOI:10.1186/s12610-023-00187-x

Xiaolei Ma, Wende Yang, Pan Nie, Zhenbin Zhang, Zehong Chen, Hongbo Wei

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引用次数: 0

摘要

背景:本研究旨在探讨皮肤源性前体雪旺细胞治疗双侧海绵状神经损伤大鼠勃起功能障碍的治疗潜力。结果:皮肤源性前体雪旺细胞处理明显恢复勃起功能，加速阴茎内皮和平滑肌组织的恢复，促进神经修复。治疗后p-Smad2/3表达降低，提示海绵体纤维化明显减轻。结论:皮肤源性前体雪旺细胞植入术是治疗双侧海绵状神经损伤所致勃起功能障碍的有效方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Implantation of skin-derived precursor Schwann cells improves erectile function in a bilateral cavernous nerve injury rat model.

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Implantation of skin-derived precursor Schwann cells improves erectile function in a bilateral cavernous nerve injury rat model.

Background: This study was conducted to investigate the therapeutic potential of the skin-derived precursor Schwann cells for the treatment of erectile dysfunction in a rat model of bilateral cavernous nerve injury.

Results: The skin-derived precursor Schwann cells-treatment significantly restored erectile functions, accelerated the recovery of endothelial and smooth muscle tissues in the penis, and promoted nerve repair. The expression of p-Smad2/3 decreased after the treatment, which indicated significantly reduced fibrosis in the corpus cavernosum.

Conclusions: Implantation of skin-derived precursor Schwann cells is an effective therapeutic strategy for treating erectile dysfunction induced by bilateral cavernous nerve injury.

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来源期刊

Basic and Clinical Andrology Medicine-Urology

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

22 weeks

期刊介绍： Basic and Clinical Andrology is an open access journal in the domain of andrology covering all aspects of male reproductive and sexual health in both human and animal models. The journal aims to bring to light the various clinical advancements and research developments in andrology from the international community.