利用大鼠检测耐药结核病。

IF 1.3 Q4 RESPIRATORY SYSTEM

Public Health Action Pub Date : 2023-03-21 DOI:10.5588/pha.22.0059

N Beyene, A L Sitotaw, E G Telila, H A Gebre, N B Alemu, R Burny, C Cox, J Soka, B Tegegn, L Wassie, K Bobosha, T Agizew

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引用次数: 0

摘要

尽管十多年前人们就已经知道用经过ontwikkeling训练的非洲巨袋大鼠检测药物敏感结核病，但以前从未探索过用大鼠检测耐药结核病(DR-TB)。我们提出了我们认为是关于使用Xpert®MTB/RIF Ultra检测到的利福平耐药结核病(RR-TB)的第一份报告，可以通过大鼠嗅闻推定结核病患者的痰样本进行比较:使用Ultra检测到的88%的RR-TB被大鼠识别出来。需要进一步评估大鼠用于大规模耐药结核病接触分诊检测的有用性，特别是在资源有限的低收入和中等收入国家。

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The use of rats to detect drug-resistant TB.

Although detection of drug-susceptible TB by Anti-Persoonsmijnen Ontmijnende Product Ontwikkeling-trained African giant pouched rats has been known for more than a decade, the detection of drug-resistant TB (DR-TB) using rats has never been explored before. We present what we believe to be the first report on rifampicin-resistant TB (RR-TB) detected using Xpert® MTB/RIF Ultra, comparably identified by rats sniffing sputum samples from presumptive TB patients: 88% of RR-TB detected using Ultra were identified by the rats. Further evaluation of the usefulness of rats for large-scale DR-TB contact triage testing is needed, especially in low- and middle-income countries, where resources are limited.

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Public Health Action RESPIRATORY SYSTEM-

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期刊介绍： Launched on 1 May 2011, Public Health Action (PHA) is an official publication of the International Union Against Tuberculosis and Lung Disease (The Union). It is an open access, online journal available world-wide to physicians, health workers, researchers, professors, students and decision-makers, including public health centres, medical, university and pharmaceutical libraries, hospitals, clinics, foundations and institutions. PHA is a peer-reviewed scholarly journal that actively encourages, communicates and reports new knowledge, dialogue and controversy in health systems and services for people in vulnerable and resource-limited communities — all topics that reflect the mission of The Union, Health solutions for the poor.