Beware of bihemispheric stroke after Omicron variant infection in the elderly.

S infection can cause thrombosis in infected individuals.[1] Thromboembolic events, including ischemic stroke, are major complications of coronavirus disease 2019 (COVID-19).[2] Among strokes, bihemispheric ischemic stroke is uncommon, suggestive of an embolic source, and associated with increased death and disability.[3] In Japan, August 2022 was the seventh wave of the COVID-19 pandemic, with approximately 200,000 people infected with Omicron variants per day. During this period, we experienced elderly patients who developed bihemispheric stroke after Omicron variant infection, all with poor prognoses. A case series in clinical practice should first be considered to determine whether Omicron variants are prone to thrombosis.